ArticleInternational orthopaedics2022
Sonication of explants enhances the diagnostic accuracy of synovial fluid and tissue cultures and can help determine the appropriate antibiotic therapy for prosthetic joint infections.
Article in International orthopaedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04304885 (Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.), which is not on this map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- The Significance of Sonication in the Detection of Peri-Implant Infections.Antibiotics (Basel, Switzerland) · 2026Article
- Microbiologic analysis of 140 patients undergoing revision total knee arthroplasty due to periprosthetic joint infection and aseptic loosening: droplet digital PCR analysis.Journal of orthopaedic surgery and research · 2025Article
- Periprosthetic joint infections: state-of-the-art.Archives of orthopaedic and trauma surgery · 2024Review
- Improving the microbiological diagnosis of fracture-related infection and prosthetic joint infection through culturing sonication fluid in Bactec blood culture bottles.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- A bio-functional cryogel with antioxidant activity for potential application in bone tissue repairing.Heliyon · 2024Article
- Sonication protocols and their contributions to the microbiological diagnosis of implant-associated infections: a review of the current scenario.Frontiers in cellular and infection microbiology · 2024Review
- The value of sonication on orthopaedic implants in an everyday clinical setting - an exploratory study.BMC musculoskeletal disorders · 2023Article
- Direct detection and identification of periprosthetic joint infection pathogens by metagenomic next-generation sequencing.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposesThis study aimed to evaluate the sensitivity and specificity of the sonication cultures according to the International Consensus Meeting 2018 criteria and to evaluate the effect of sonication on the antibiotic treatment of patients.
methodsSixty-four patients who were scheduled for revision hip or knee arthroplasties were included in the study. Aspiration fluid, tissue, and sonication cultures were performed from all patients and compared in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy. Other targets of the study were to investigate the rate of change in the antibiotic treatment.
resultsThe sensitivity, specificity, PPV, NPV, and overall accuracy of the fluid culture obtained by the sonication method were 71.4%, 96.6%, 96.2%, 73.7%, and 82.8%, respectively. The sensitivity, specificity, PPV, NPV, and overall accuracy of the fluid culture obtained after tissue sampling were 68.6%, 100%, 100.0%, 72.5%, and 82.8%, respectively. There was no statistically significant difference between the sonication method and tissue culture in terms of sensitivity and specificity (p = 1.0). The sensitivity, specificity, PPV, NPV, and overall accuracy of the fluid culture obtained by the aspiration method were 28.6%, 93.1%, 83.3%, 51.9%, and 57.8%, respectively. Treatment change was applied in 10 (15.6%) patients.
conclusionOur prospectively collected data revealed that sonication of the explants alone did not increase the sensitivity, and we found that sonicate culture sometimes changed the antibiotic therapy strategy in patients with periprosthetic joint infection because different microorganisms were detected.
trial registrationThis study was prospectively registered in a public trials registry ( https://clinicaltrials.gov/ , NCT04304885).
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