Evidence map›Paper›PMID 35067138›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs.

Krystian Pyta, Natalia Skrzypczak, Piotr Ruszkowski, Franz Bartl, Piotr Przybylski

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Krystian PytaFaculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Natalia SkrzypczakFaculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Piotr RuszkowskiDepartment of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland.
Franz BartlLebenswissenschaftliche Fakultät, Institut für Biologie, Biophysikalische Chemie Humboldt-Universität zu Berlin Invalidenstraße 42, Berlin, Germany.
Piotr PrzybylskiFaculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.ORCID 0000-0001-8072-5877
Adam Mickiewicz University in Poznań · PLHumboldt-Universität zu Berlin · DEPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The influence of base type, temperature, and solvent on regioselective C(9)/C(10) "

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalColchicineDose-Response Relationship, DrugDrug Screening Assays, AntitumorHeterocyclic CompoundsHumansMolecular Docking SimulationMolecular StructureStereoisomerismStructure-Activity RelationshipTropoloneTubulinTubulin ModulatorsAntineoplastic AgentsColchicineHeterocyclic CompoundsTropoloneTubulinTubulin ModulatorsanticancerclickColchiceine tautomersheck reactiontubulin inhibitors

Identifiers

PMID35067138
PMCPMC8788354
OpenAlexW4206992973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.