Evidence map›Paper›PMID 35067102›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

Allele-specific silencing by RNAi of R92Q and R173W mutations in cardiac troponin T.

Loredana Migliore, Federico Galvagni, Enrico Pierantozzi, Vincenzo Sorrentino, Daniela Rossi

Open access · greenAbstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. RNA-Based Therapies for Treating Monogenic Cardiomyopathies.The Canadian journal of cardiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Loredana MiglioreDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0395-1496
Federico GalvagniDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Enrico PierantozziDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Vincenzo SorrentinoDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Daniela RossiDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0463-7327
University of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autosomal dominant mutations in sarcomere proteins such as the cardiac troponin T (

Indexed as

Cardiomyopathy, DilatedCardiomyopathy, HypertrophicAllelesHEK293 CellsHumansMutationRNA InterferenceTroponin TTNNT2 protein, humanTroponin Tcardiomyopathygene therapyluciferase assayRNA interference

Identifiers

PMID35067102
PMCPMC9160939
OpenAlexW4206951548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.