ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022
Genetic load and extinction in peripheral populations: the roles of migration, drift and demographic stochasticity.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Genomic Signatures in Maned Three-Toed Sloths From Ancient to Recent Environmental Changes in Brazil's Threatened Atlantic Forest.Molecular ecology · 2025Article
- Margins of adaptation at the desert frontier: genetic responses of Ammopiptanthus mongolicus in arid northwestern China.Botanical studies · 2025Review
- When birds of a feather flock together: Severe genomic erosion and the implications for genetic rescue in an endangered island passerine.Evolutionary applications · 2024Article
- Non-random mating within an Island rookery of Hawaiian hawksbill turtles: demographic discontinuity at a small coastline scale.Royal Society open science · 2023Article
- Introduction to the theme issue 'Species' ranges in the face of changing environments'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Understanding the biology of species' ranges: when and how does evolution change the rules of ecological engagement?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The response of a metapopulation to a changing environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Preface.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a 'semi-deterministic' analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue 'Species' ranges in the face of changing environments (part I)'.
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