SynthesisInternal medicine journal2022
Frailty and mortality associations in patients with COVID-19: a systematic review and meta-analysis.
Synthesis in Internal medicine journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic Factors of COVID-19: An Umbrella Review Endorsed by the International Society for Pharmacoepidemiology.Clinical pharmacology and therapeutics · 2023Pooled it
- Recognise, respond, reflect: A value-based framework for rapid response teams.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Exploring how older adults perceived the impact of infectious diseases and vaccines on ageing: a cross-sectional study in France.BMC geriatrics · 2026Article
- Sex and the Multidimensional Prognostic Index in 3.5-year post-COVID-19 mortality among older adults: evidence of a time-varying effect.Internal and emergency medicine · 2026Article
- COVID-19-Relevant Insights Into the Elevated Risk of Accidental Injuries in Survivors of SARS and Their Relatives in Taiwan: Retrospective Cohort Study.JMIR public health and surveillance · 2025Article
- The desire of autonomy: A lever for vaccination of the elderly? Results of a qualitative study.Human vaccines & immunotherapeutics · 2024Article
- Limited incremental predictive value of the frailty index and other vulnerability measures from routine care data for mortality risk prediction in older patients with COVID-19 in primary care.BMC primary care · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Clinical characteristics and outcomes of COVID-19 patients with preexisting dementia: a large multicenter propensity-matched Brazilian cohort study.BMC geriatrics · 2024Observational
- Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia.Tropical medicine and infectious disease · 2024Article
- Frailty in Critically Ill Patients with COVID-19: The Lessons Learned.Advances in experimental medicine and biology · 2024Review
- The Role of Surgical Prehabilitation During the COVID-19 Pandemic and Beyond.Physical medicine and rehabilitation clinics of North America · 2023Review
- Mortality Risks after Two Years in Frail and Pre-Frail Older Adults Admitted to Hospital.Journal of clinical medicine · 2023Article
- The impact of age on intensive care.Ageing research reviews · 2023Review
- Association between Clinical Frailty Scale (CFS) and clinical presentation and outcomes in older inpatients with COVID-19.BMC geriatrics · 2023Article
- Association between a Frailty Index from Common Laboratory Values and Vital Signs (FI-LAB) and Hospital and Post-Hospital Outcomes in Veterans with COVID-19 Infection.The journal of nutrition, health & aging · 2023Article
- Impact of frailty on clinical outcomes in patients with and without COVID-19 pneumonitis admitted to intensive care units in Australia and New Zealand: a retrospective registry data analysis.Critical care (London, England) · 2022Article
- COVID-19: Some unresolved issues.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Review
- Frailty in the context of COVID-19 pandemic: A life-threatening condition.Frontiers in medicine · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational data during the pandemic have demonstrated mixed associations between frailty and mortality.
aimTo examine associations between frailty and short-term mortality in patients hospitalised with coronavirus disease 2019 (COVID-19).
methodsIn this systematic review and meta-analysis, we searched PubMed, Embase and the COVID-19 living systematic review from 1 December 2019 to 15 July 2021. Studies reporting mortality and frailty scores in hospitalised patients with COVID-19 (age ≥18 years) were included. Data on patient demographics, short-term mortality (in hospital or within 30 days), intensive care unit (ICU) admission and need for invasive mechanical ventilation (IMV) were extracted. The quality of studies was assessed using the Newcastle-Ottawa Scale.
resultsTwenty-five studies reporting 34 628 patients were included. Overall, 26.2% (n = 9061) died. Patients who died were older (76.7 ± 9.6 vs 69.2 ± 13.4), more likely male (risk ratio (RR) = 1.08; 95% confidence interval (CI): 1.06-1.11) and had more comorbidities. Fifty-eight percent of patients were frail. Adjusting for age, there was no difference in short-term mortality between frail and non-frail patients (RR = 1.04; 95% CI: 0.84-1.28). The non-frail patients were commonly admitted to ICU (27.2% (4256/15639) vs 29.1% (3567/12274); P = 0.011) and had a higher mortality risk (RR = 1.63; 95% CI: 1.30-2.03) than frail patients. Among patients receiving IMV, there was no difference in mortality between frail and non-frail (RR = 1.62; 95% CI 0.93-2.77).
conclusionThis systematic review did not demonstrate an independent association between frailty status and short-term mortality in patients with COVID-19. Patients with frailty were less commonly admitted to ICU and non-frail patients were more likely to receive IMV and had higher mortality risk. This finding may be related to allocation decisions for patients with frailty amidst the pandemic.
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