Evidence map›Paper›PMID 35066877›Full record

ArticleThe Journal of pathology2022

Genetic context of oncogenic drivers dictates vascular sarcoma development in aP2-Cre mice.

Jason A Hanna, Casey G Langdon, Matthew R Garcia, Annaleigh Benton, Nadia A Lanman, David Finkelstein, Jerold E Rehg, Mark E Hatley

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. miR-497 Target Gene Regulatory Network in Angiosarcoma.Molecular cancer research : MCR · 2024
    Article
  7. Review
  8. Article
  9. Target gene regulatory network of miR-497 in angiosarcoma.bioRxiv : the preprint server for biology · 2023
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jason A HannaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7253-7964
Casey G LangdonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0010-7209
Matthew R GarciaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Annaleigh BentonDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Nadia A LanmanPurdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
David FinkelsteinDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jerold E RehgDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mark E HatleyDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7147-3946
St. Jude Children's Research Hospital · USPurdue University West Lafayette · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Defining the non-myogenic origins of pediatric rhabdomyosarcomaR01CA216344 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HATLEY, MARK EDWARD · 2017 to 2021
$2.0M
Mediators Of Arrested Differentiation In Pediatric RhabdomyosarcomaR01CA251436 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HATLEY, MARK EDWARD · 2021 to 2025
$2.0M
NCI NIH HHS P30 CA021765NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA216344NCI NIH HHS R01 CA251436
6 · The paper itself

Abstract

Angiosarcomas are aggressive vascular sarcomas that arise from endothelial cells and have an extremely poor prognosis. Because of the rarity of angiosarcomas, knowledge of molecular drivers and optimized treatment strategies is lacking, highlighting the need for in vivo models to study the disease. Previously, we generated genetically engineered mouse models of angiosarcoma driven by aP2-Cre-mediated biallelic loss of Dicer1 or conditional activation of Kras

Indexed as

HemangiosarcomaSoft Tissue NeoplasmsAnimalsCarcinogenesisEndothelial CellsIntegrasesMiceProto-Oncogene Proteins p21(ras)TOR Serine-Threonine KinasesCre recombinaseIntegrasesProto-Oncogene Proteins p21(ras)TOR Serine-Threonine KinasesangiosarcomaDICER1kaposiform hemangioendotheliomasarcomaTSC1

Identifiers

PMID35066877
PMCPMC9007915
OpenAlexW4206971250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.