Evidence map›Paper›PMID 35066866›Full record

ArticleJournal of the science of food and agriculture2022

Effects of dietary supplementation with multispecies probiotics on intestinal epithelial development and growth performance of neonatal calves challenged with Escherichia coli K99.

Yan-Yan Wu, Cun-Xi Nie, Chunsheng Xu, Rui-Qing Luo, Hong-Li Chen, Jun-Li Niu, Xue Bai, Wenju Zhang

Open access · hybridAbstract readRandomized Controlled Trial, Veterinary
In one paragraph

Article in Journal of the science of food and agriculture, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Frontiers in microbiology · 2026
    Article
  3. Article
  4. Article
  5. Probiotic characteristics and whole genome sequencing ofFrontiers in veterinary science · 2025
    Article
  6. International journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yan-Yan WuCollege of Animal Science and Technology, Shihezi University, Shihezi, China.ORCID https://orcid.org/0000-0003-1451-4603
Cun-Xi NieCollege of Animal Science and Technology, Shihezi University, Shihezi, China.
Chunsheng XuCollege of Animal Science and Technology, Shihezi University, Shihezi, China.
Rui-Qing LuoXinjiang Tianshan Junken Animal Husbandry Co. Ltd, Shihezi, China.
Hong-Li ChenXinjiang Tianshan Junken Animal Husbandry Co. Ltd, Shihezi, China.
Jun-Li NiuCollege of Animal Science and Technology, Shihezi University, Shihezi, China.
Xue BaiCollege of Animal Science and Technology, Shihezi University, Shihezi, China.
Wenju ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi, China.
Shihezi University · CNAnimal Husbandry & Veterinary · IN

Funding

Major Science and Technology Project of Xinjiang Production and Construction Corps 2021AA004Modern Agricultural Science and Technology Research and Achievement Transformation Project of the Eighth Division 2018NY05the Key Scientific and Technological Research Project in Key Fields of Xinjiang Production and Construction Corps 2018AB041the Program for Science and Technology Innovation Talents in Xinjiang Production and Construction Corps 2020CB023
6 · The paper itself

Abstract

backgroundProbiotics exhibit antibiotic properties and are capable of treating certain bacterial infections, including diarrhea. Therefore, the aim of this study is to investigate the effects of dietary supplementation with multispecies probiotic (MSP) on diarrhea, average daily gain (ADG) and intestinal development of neonatal calves challenged with Escherichia coli K99.

resultsThirty-six neonatal Holstein calves were randomly assigned to three treatment groups. After E. coli K99 challenge, calves in the control (C) and MSP treatment groups had significantly higher ADG and feed efficiency, and significantly lower fecal scores than those of calves in the diarrhea (D) group. The mean time of diarrhea resolution was 4.5 and 3.1 days for calves in the D and MSP treatment groups, respectively. Furthermore, the structures of the various segments (duodenum, jejunum and ileum) of the small intestine of the calves, activities of several small intestinal enzymes, and expression of several energy metabolism-related genes in the small intestine segments were significantly affected by MSP treatments.

conclusionDietary supplementation of MSP had a positive effect in treating calf diarrhea; it improved ADG and feed efficiency and promoted development of the small intestine. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Escherichia coliProbioticsAnimal FeedAnimalsCattleDiarrheaDietGrowth and DevelopmentWeaningdiarrheaintestinal developmentneonatal calvesprobiotic

Identifiers

PMID35066866
PMCPMC9303730
OpenAlexW4206971832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.