Evidence map›Paper›PMID 35066815›Full record

ReviewTranslational stroke research2022

The Fate of Erythrocytes after Cerebral Hemorrhage.

Fan Xia, Richard F Keep, Fenghui Ye, Katherine G Holste, Shu Wan, Guohua Xi, Ya Hua

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Roles of Microglia in Cerebral Small Vessel Disease.CNS neuroscience & therapeutics · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Nanobiotechnologies for stroke treatment.Nanomedicine (London, England) · 2025
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fan XiaDepartment of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Fenghui YeDepartment of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Katherine G HolsteDepartment of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Shu WanDepartment of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA. guohuaxi@umich.edu.ORCID http://orcid.org/0000-0003-2846-5937
Ya HuaDepartment of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA. yahua@umich.edu.
University of Michigan · USSichuan University · CN

Funding

Experimental Cerebral Hemorrhage: Mechanisms and TherapiesR35NS116786 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2020 to 2024
$5.2M
Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhageR01NS106746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2018 to 2022
$2.5M
Targeting CD47 to aid in clearing intracerebral hemorrhagesR01NS096917 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA, XI, GUOHUA · 2016 to 2020
$1.7M
Peroxiredoxin-2 and Intracerebral Hemorrhage-Induced Brain InjuryR21NS112394 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2019 to 2019
$429k
NINDS NIH HHS NS116786NINDS NIH HHS R01 NS096917NINDS NIH HHS R01 NS106746NINDS NIH HHS R21 NS112394NINDS NIH HHS R35 NS116786
6 · The paper itself

Abstract

After a cerebral hemorrhage (intracerebral, subarachnoid, and intraventricular), extravasated blood contributes to both initial brain injury, via physical disruption and mass effect, and secondary injury, through the release of potentially neurotoxic and pro-inflammatory factors such as hemoglobin, iron, and peroxiredoxin-2. Erythrocytes are a major blood component and are a source of such damaging factors. Erythrolysis after cerebral hemorrhage releases potential neurotoxins, contributing to brain injury and edema. Alternatively, erythrocyte phagocytosis via microglia or macrophages may limit the spill of neurotoxins therefore limiting subsequent brain injury. The aim of this review is to discuss the process of phagocytosis of erythrocytes by microglia or macrophages after cerebral hemorrhage, the effect of erythrolysis on brain injury, novel mechanisms of erythrocyte and phagocyte egress from the brain, and exciting new targets in this pathway to attenuate brain injury. Understanding the fate of erythrocytes after cerebral hemorrhage may uncover additional potential interventions for clinical translational research.

Indexed as

Brain InjuriesNeurotoxinsCerebral HemorrhageErythrocytesHemolysisHumansMicrogliaNeurotoxinsCerebral hemorrhageComplementErythrocytesErythrolysisMacrophagesMicrogliaPhagocytosis

Identifiers

PMID35066815
PMCPMC9782724
OpenAlexW4207079004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.