Evidence map›Paper›PMID 35066369›Full record

ArticlePediatric neurology2022

Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C.

Ericka L Fink, Courtney L Robertson, Mark S Wainwright, Juan D Roa, Marlina E Lovett, Casey Stulce, Mais Yacoub, Renee M Potera, Elizabeth Zivick, Adrian Holloway and 46 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  20. SARS-CoV-2 Infection and COVID-19 in Children.Clinics in chest medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors at 20 institutions in 5 countries.

Ericka L FinkDivision of Pediatric Critical Care Medicine, Department of Critical Care Medicine, Pittsburgh, Pennsylvania; Safar Center for Resuscitation Research, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: finkel@ccm.upmc.edu.
Courtney L RobertsonDepartments of Anesthesiology and Critical Care Medicine, and Pediatrics of The Johns Hopkins University SOM, Baltimore, Maryland.
Mark S WainwrightDivision of Pediatric Neurology, University of Washington, Seattle Children's Hospital, Seattle, Washington.
Juan D RoaDepartment of Pediatrics, Universidad Nacional de Colombia and Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia.
Marlina E LovettDivision of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.
Casey StulceDepartment of Pediatrics, University of Chicago, Chicago, Illinois.
Mais YacoubDivision of Critical Care, Department of Pediatrics, UMC Children's Hospital, Las Vegas, Nevada.
Renee M PoteraDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Elizabeth ZivickDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
Adrian HollowayDivision of Critical Care, Department of Pediatrics, University of Maryland Medical Center, Baltimore, Maryland.
Ashish NagpalDepartment of Pediatrics, Section of Critical Care Medicine, Oklahoma Children's Hospital at OU health, Oklahoma University College of Medicine, Oklahoma City, Oklahoma.
Kari WellnitzDivision of Pediatric Critical Care, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Theresa CzechDivision of Pediatric Neurology, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Katelyn M EvenDivision of Pediatric Critical Care Medicine, Penn State College of Medicine, Hershey, Pennsylvania.
Werther Brunow de CarvalhoDepartment of Pediatrics, University of São Paulo, São Paulo, Brazil.
Isadora Souza RodriguezDepartment of Pediatrics, University of São Paulo, São Paulo, Brazil.
Stephanie P SchwartzDepartment of Pediatrics, University of North Carolina at Chapel Hill Hospitals, Chapel Hill, North Carolina.
Tracie C WalkerDepartment of Pediatrics, University of North Carolina at Chapel Hill Hospitals, Chapel Hill, North Carolina.
Santiago Campos-MiñoPediatric Intensive Care Unit, Hospital Metropolitano, Quito, Ecuador.
Leslie A DervanDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
Andrew S GeneslawDivision of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.
Taylor B SewellDivision of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.
Patrice PryceDivision of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, Morgan Stanley Children's Hospital New York-Presbyterian Hospital, New York, New York.
Wendy G SilverDivision of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York.
Jieru Egeria LinDivision of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York.
Wendy S VargasDivision of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York.
Alexis TopjianDivision of Critical Care Medicine at The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Alicia M AlcamoDivision of Critical Care Medicine at The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Jennifer L McGuireDivision of Neurology at The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Jesus Angel Domínguez RojasDivision of Pediatric Critical Care, Department of Pediatrics, Hospital de Emergencia Villa El Salvador, Lima, Peru.
Jaime Tasayco MuñozDivision of Pediatric Critical Care, Department of Pediatrics, Hospital de Emergencia Villa El Salvador, Lima, Peru.
Sue J HongDepartment of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
William J MullerDepartment of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Matthew DoerflerDepartment of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Cydni N WilliamsDivision of Pediatric Critical Care, Department of Pediatrics Pediatric Critical Care and Neurotrauma Recovery Program Portland, Oregon Health & Science University, Oregon.
Kurt DruryDivision of Pediatric Critical Care, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.
Dhristie BhagatDepartment of Neurology, NYU Langone Health, New York, New York.
Aaron NelsonDepartment of Neurology, NYU Langone Health, New York, New York.
Dana PriceDepartment of Neurology, NYU Langone Health, New York, New York.
Heda DapulDivision of Pediatric Critical Care, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, New York.
Laura SantosDivision of Pediatric Critical Care, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, New York.
Robert KahoudDivision of Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
Conall FrancoeurDepartment of Pediatrics, CHU de Québec - Université Laval Research Center, Quebec City, Quebec, Canada.
Brian AppavuDivision of Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, University of Arizona, College of Medicine, Phoenix, Arizona.
Kristin P GuilliamsDepartments of Neurology, Pediatrics, and Radiology, Washington University in St. Louis, St. Louis, Missouri.
Shannon C AgnerDepartments of Neurology, Pediatrics, and Radiology, Washington University in St. Louis, St. Louis, Missouri.
Karen H WalsonDepartment of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia.
Lindsey RasmussenPediatric Critical Care Medicine, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
Anna JanasPediatric Critical Care Medicine, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
Peter FerrazzanoDepartment of Pediatrics, University of Wisconsin, Madison, Wisconsin.
Raquel Farias-MoellerDivision Child Neurology, Department of Neurology, Medical College of Wisconsin, Children's Wisconsin, Milwaukee, Wisconsin.
Kellie C SnooksDepartment of Pediatrics, Medical College of Wisconsin, Children's Wisconsin, Milwaukee, Wisconsin.
Chung-Chou H ChangDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
James YunDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Michelle E SchoberDivision of Critical Care of the University of Utah, Department of Pediatrics, Salt Lake City, Utah.
Global Consortium Study of Neurologic Dysfunction in COVID-19 (GCS-NeuroCOVID) Investigators
Columbia University Irving Medical Center · USNYU Langone Health · USLurie Children's Hospital · USOregon Health & Science University · USStanford University · USUniversidade de São Paulo · BRUniversity of Iowa · USUniversity of North Carolina Hospitals · USUniversity of Pennsylvania · USUniversity of Pittsburgh · USWashington University in St. Louis · USChildren's Healthcare of Atlanta · USChildren's Heart Center Nevada · USChildren's Hospital of Oklahoma · USChildren's Hospital of Philadelphia · USChildren's Hospital of Pittsburgh · USChildren's Hospital of Wisconsin · USHospital Metropolitano · ECJohns Hopkins University · USMayo Clinic · US

Funding

Sleep Management And Recovery after Traumatic Brain Injury in Kids (SMART-Kids): Evidence for targeting sleep to improve outcomesK23HL150229 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, CYDNI NICOLE · 2020 to 2024
$790k
NHLBI NIH HHS K23 HL150229
6 · The paper itself

Abstract

backgroundOur objective was to characterize the frequency, early impact, and risk factors for neurological manifestations in hospitalized children with acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or multisystem inflammatory syndrome in children (MIS-C).

methodsMulticenter, cross-sectional study of neurological manifestations in children aged <18 years hospitalized with positive SARS-CoV-2 test or clinical diagnosis of a SARS-CoV-2-related condition between January 2020 and April 2021. Multivariable logistic regression to identify risk factors for neurological manifestations was performed.

resultsOf 1493 children, 1278 (86%) were diagnosed with acute SARS-CoV-2 and 215 (14%) with MIS-C. Overall, 44% of the cohort (40% acute SARS-CoV-2 and 66% MIS-C) had at least one neurological manifestation. The most common neurological findings in children with acute SARS-CoV-2 and MIS-C diagnosis were headache (16% and 47%) and acute encephalopathy (15% and 22%), both P < 0.05. Children with neurological manifestations were more likely to require intensive care unit (ICU) care (51% vs 22%), P < 0.001. In multivariable logistic regression, children with neurological manifestations were older (odds ratio [OR] 1.1 and 95% confidence interval [CI] 1.07 to 1.13) and more likely to have MIS-C versus acute SARS-CoV-2 (OR 2.16, 95% CI 1.45 to 3.24), pre-existing neurological and metabolic conditions (OR 3.48, 95% CI 2.37 to 5.15; and OR 1.65, 95% CI 1.04 to 2.66, respectively), and pharyngeal (OR 1.74, 95% CI 1.16 to 2.64) or abdominal pain (OR 1.43, 95% CI 1.03 to 2.00); all P < 0.05.

conclusionsIn this multicenter study, 44% of children hospitalized with SARS-CoV-2-related conditions experienced neurological manifestations, which were associated with ICU admission and pre-existing neurological condition. Posthospital assessment for, and support of, functional impairment and neuroprotective strategies are vitally needed.

Indexed as

SARS-CoV-2Acute DiseaseAdolescentBrain DiseasesChildChild, PreschoolCOVID-19Cross-Sectional StudiesFemaleHeadacheHumansInfantIntensive Care Units, PediatricLogistic ModelsMaleNervous System DiseasesChild developmentNeurological manifestationsPediatricsSARS-CoV-2

Identifiers

PMID35066369
PMCPMC8713420
OpenAlexW4200103105

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.