Evidence map›Paper›PMID 35066311›Full record

ArticlePsychiatry research2022

Heightened autonomic reactivity to negative affective stimuli among active duty soldiers with PTSD and opioid-treated chronic pain.

Carter E Bedford, Yoshio Nakamura, William R Marchand, Eric L Garland

Open access · greenAbstract read
In one paragraph

Article in Psychiatry research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carter E BedfordFlorida State University, Department of Psychology, 1107W. Call St., Tallahassee, FL 32306 USA.
Yoshio NakamuraUniversity of Utah, Department of Anesthesiology, Pain Research Center, Salt Lake City, UT 84112, USA; University of Utah, Center on Mindfulness and Integrative Health Intervention Development, 395 1500 E, Salt Lake City, UT 84112, USA.
William R MarchandSalt Lake Veterans Administration Medical Center, Salt Lake City, UT 84112, USA; University of Utah, Department of Psychiatry, 501 Chipeta Way, Salt Lake City, UT 84108, USA.
Eric L GarlandSalt Lake Veterans Administration Medical Center, Salt Lake City, UT 84112, USA; University of Utah, College of Social Work, 395 1500 E, Salt Lake City, UT 84112, USA; University of Utah, Center on Mindfulness and Integrative Health Intervention Development, 395 1500 E, Salt Lake City, UT 84112, USA. Electronic address: eric.garland@socwk.utah.edu.
University of Utah · USFlorida State University · US

Funding

Targeting Hedonic Dysregulation to Address Chronic Pain and Opioid Misuse in Primary Care.R01DA042033 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2016 to 2020
$2.8M
Targeting Military Opioid Misuse with Mindfulness-Oriented Recovery EnhancementR34DA037005 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2013 to 2015
$667k
NIDA NIH HHS R01 DA042033NIDA NIH HHS R34 DA037005
6 · The paper itself

Abstract

Within military populations, chronic pain conditions and posttraumatic stress disorder (PTSD) frequently co-occur, however, little research has examined the psychophysiological correlates of this comorbidity among active-duty soldiers. The current study examined physiological reactivity to negative affective stimuli among 30 active duty soldiers with chronic pain conditions treated with long-term opioid therapy. Participants completed a diagnostic interview and self-report measures. Then, their heart rate and skin temperature were recorded during an affective picture-viewing task. Soldiers with PTSD exhibited greater increases in the ratio of low-to-high frequency heart rate variability (LF/HF HRV) while viewing negative affective images than soldiers without PTSD. PTSD symptom severity was positively associated with LF/HF HRV reactivity and negatively associated with skin temperature reactivity. Additionally, opioid craving was associated with LF/HF HRV and skin temperature reactivity among soldiers with PTSD. Taken together, the results of the present study provide evidence for heightened sympathetic nervous system reactivity among soldiers with comorbid chronic pain and PTSD, underscoring the importance of intervening on potential risk factors for these conditions.

Indexed as

Chronic PainMilitary PersonnelStress Disorders, Post-TraumaticAnalgesics, OpioidAutonomic Nervous SystemHeart RateHumansAnalgesics, OpioidCue-reactivityHRVMilitaryOpioidsPainPsychophysiologyPTSD

Identifiers

PMID35066311
PMCPMC8928316
OpenAlexW4205774488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.