ArticleMolecular metabolism2022
Dissecting a disynaptic central amygdala-parasubthalamic nucleus neural circuit that mediates cholecystokinin-induced eating suppression.
Article in Molecular metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- A Distinct Subpopulation of Extended Amygdala Neurons Drives Food Intake.Biological psychiatry global open science · 2026Article
- Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence.bioRxiv : the preprint server for biology · 2026Article
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Whole-Brain Monosynaptic Inputs to Parasubthalamic Calretinin Neurons in Mice.Molecular neurobiology · 2025Article
- Downstream interaction by glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonism is required for synergistic effects on body weight.Molecular metabolism · 2025Article
- A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Regulation of PVT-CeA Circuit in Deoxynivalenol-Induced Anorexia and Aversive-Like Emotions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tachykinin-1-expressing parasubthalamic nucleus neurons are necessary for odorant-induced appetite suppression.Physiology & behavior · 2025Article
- Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics.Nature communications · 2025Article
- The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking.Molecular psychiatry · 2025Article
- Neural circuits regulation of satiation.Appetite · 2024Review
- Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024Article
- Vagal innervation limits brain injury by inhibiting gut-selective integrin-mediated intestinal immunocyte migration in intracerebral hemorrhage.Theranostics · 2024Article
- Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice.Nature communications · 2023Article
- Experience-dependent changes in affective valence of taste in male mice.Molecular brain · 2023Article
- Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.Nature communications · 2022Article
- A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression.eLife · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveCholecystokinin (CCK) plays a critical role in regulating eating and metabolism. Previous studies have mapped a multi-synapse neural pathway from the vagus nerve to the central nucleus of the amygdala (CEA) that mediates the anorexigenic effect of CCK. However, the neural circuit downstream of the CEA is still unknown due to the complexity of the neurons in the CEA. Here we sought to determine this circuit using a novel approach.
methodsIt has been established that a specific population of CEA neurons, marked by protein kinase C-delta (PKC-δ), mediates the anorexigenic effect of CCK by inhibiting other CEA inhibitory neurons. Taking advantage of this circuit, we dissected the neural circuit using a unique approach based on the idea that neurons downstream of the CEA should be disinhibited by CEA
resultsWe found that neurons in the parasubthalamic nucleus (PSTh) are activated by the activation of CEA
conclusionsOur results identified a disynaptic CEA-PSTh neural circuit that mediates the anorexigenic effect of CCK and thus provide an important neural mechanism of how CCK suppresses eating.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.