Evidence map›Paper›PMID 35066157›Full record

ArticleNeuroImage2022

Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults.

Shengwen Deng, Crystal G Franklin, Michael O'Boyle, Wei Zhang, Betty L Heyl, Paul A Jerabek, Hanzhang Lu, Peter T Fox

Abstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  11. Imaging brain energetics to advance metabolic psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  15. Observational
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  18. Review
  19. Aging and the Spectral Properties of Brain Hemodynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shengwen DengResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA; Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Crystal G FranklinResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Michael O'BoyleResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Wei ZhangResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Betty L HeylResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Paul A JerabekResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Hanzhang LuThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; South Texas Veterans Health Care System, San Antonio, TX, USA. Electronic address: fox@uthscsa.edu.

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Normalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6M
ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model SystemsU01AG052409 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2016 to 2020
$1.6M
NIA NIH HHS P30 AG066546NIA NIH HHS U01 AG052409NIMH NIH HHS R01 MH074457NIMH NIH HHS R01 MH084021NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

Voxel-based physiological (VBP) variables derived from blood oxygen level dependent (BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF), fractional amplitude of low frequency fluctuations (fALFF) and regional homogeneity (ReHo). Although these BOLD-derived variables can detect between-group (e.g. disease vs control) spatial pattern differences, physiological interpretations are not well established. The primary objective of this study was to quantify spatial correspondences between BOLD VBP variables and PET measurements of cerebral metabolic rate and hemodynamics, being well-validated physiological standards. To this end, quantitative, whole-brain PET images of metabolic rate of glucose (MRGlu;

Indexed as

Positron-Emission TomographyAdultBlood Flow VelocityBlood VolumeBrainFemaleGlucoseHealthy VolunteersHemodynamicsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleOxygenReproducibility of ResultsRestGlucoseOxygenALFFBOLDBrainfALFFfMRIHemodynamicsMetabolismPETReHoVBPVoxel-Based Physiology

Identifiers

PMID35066157
PMCPMC9201851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.