ArticleLife sciences in space research2022
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice.
Article in Life sciences in space research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025Pooled it
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.Life sciences in space research · 2025Article
- Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms to organ-level impacts.Military Medical Research · 2024Review
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model.Life sciences in space research · 2023Article
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart.Life (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeAstronauts in space vehicles beyond low-Earth orbit will be exposed to high charge and energy (HZE) ions, and there is concern about potential adverse effects on the cardiovascular system. Thus far, most animal studies that assess cardiac effects of HZE particles have included only males. This study assessed the effects of oxygen ions ( MATERIALS AND
methodsFemale C57BL/6 J mice at 6 months of age were exposed to
resultsUltrasonography revealed increased left ventricle mass, diastolic volume and diameter but there was no change in the abdominal aorta. There was no indication of cardiac fibrosis however, a 75 kDa peptide of left ventricular collagen type III and α-smooth muscle cell actin were increased suggesting some remodeling had occurred. Left ventricular protein levels of the T-cell marker CD2 was significantly increased at all time points, while the neutrophil marker myeloperoxidase was decreased at 2 weeks and 9 months.
conclusionsThese results taken together suggest
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.