ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022
Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry.
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Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Thyroid disorders and COVID-19: a comprehensive review of literature.Frontiers in endocrinology · 2025Pooled it
- Comparative analysis of clinical profile, laboratory profile and outcome in COVID-19 patients with and without hypothyroidism.Ghana medical journal · 2024Observational
- Thyroid dysfunction in COVID-19.Nature reviews. Endocrinology · 2024Review
- Clinical presentation and prognosis of COVID-19 in older adults with hypothyroidism: data from the GeroCovid observational study.Journal of endocrinological investigation · 2023Observational
- Impact of COVID-19 on thyroid gland functions with reference to Graves' disease: A systematic review.Journal of family medicine and primary care · 2023Review
- The Influence of SARS-CoV-2 Infection on the Thyroid Gland.Biomedicines · 2023Review
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Authors and funding
64 authors at 20 institutions in 6 countries.
Daniella Nunes PereiraUniversidade Federal de Minas Gerais. Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil. Electronic address: dani_nunesp@hotmail.com.
Leticia Ferreira Gontijo SilveiraEndocrinology Unit, Department of Internal Medicine, Faculdade de Medicina da Universidade Federal de Minas Gerais. Avenida Professor Alfredo Balena 190, Belo Horizonte, Brazil. Electronic address: leticiafgs@ufmg.br.
Milena Maria Moreira GuimarãesEndocrinology Unit, Department of Internal Medicine, Faculdade de Medicina da Universidade Federal de Minas Gerais. Avenida Professor Alfredo Balena 190, Belo Horizonte, Brazil. Electronic address: milenamg2@gmail.com.
Carísi Anne PolanczykInternal Medicine Department. Universidade Federal do Rio Grande do Sul. Coordinator of the Institute for Health Technology Assessment (IATS/CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507, Porto Alegre, Brazil. Electronic address: carisi.anne@gmail.com.
Aline Gabrielle Sousa NunesHospital Unimed-BH. Av do Contorno, 3097, Belo Horizonte, Brazil. Electronic address: alinegsn89@yahoo.com.br.
André Soares de Moura CostaHospitais da Rede Mater Dei, Belo Horizonte, Brazil. Electronic address: andresmc@gmail.com.
Barbara Lopes FaraceHospital Risoleta Tolentino Neves. Rua das Gabirobas, 01, Belo Horizonte, Brazil. Electronic address: barbarafarace@gmail.com.
Christiane Corrêa Rodrigues CiminiHospital Santa Rosália, Teófilo Otoni, Brazil. Electronic address: christiane.cimini@gmail.com.
Cíntia Alcantara de CarvalhoHospital João XXIII. Av. Professor Alfredo Balena, 400, Belo Horizonte, Brazil. Electronic address: carvalho.cintiaa@gmail.com.
Daniela PonceHospital das Clínicas da Faculdade de Medicina de Botucatu. Botucatu, Brazil. Electronic address: daniela.ponce@unesp.br.
Eliane Würdig RoeschHospital de Clínicas de Porto Alegre. Av. Ramiro Barcellos, 2350, Porto Alegre, Brazil. Electronic address: eroesch@hcpa.edu.br.
Euler Roberto Fernandes ManentiHospital Mãe de Deus, Porto Alegre, Brazil. Electronic address: eulermanenti@gmail.com.
Fernanda Barbosa LucasHospital Santo Antônio, Curvelo, Brazil. Electronic address: fbl_lucas@yahoo.com.br.
Fernanda d'Athayde RodriguesHospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul. Av. Ramiro Barcellos, 2350, Porto Alegre, Brazil. Electronic address: fe.athayde@gmail.com.
Fernando AnschauGraduation Program on Evaluation and Production of Technologies for the Brazilian National Health System, Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Av. Francisco Trein, 326, Porto Alegre, Brazil. Electronic address: afernando@ghc.com.br.
Fernando Graça AranhaHospital SOS Cárdio, Florianópolis, Brazil. Electronic address: fgaranha@icloud.com.
Frederico BartolazziHospital Santo Antônio, Curvelo, Brazil. Electronic address: fredlazzi@hotmail.com.
Giovanna Grunewald ViettaHospital SOS Cárdio, Florianópolis, Brazil. Electronic address: ggvietta@gmail.com.
Guilherme Fagundes NascimentoHospital Unimed-BH. Av do Contorno, 3097, Belo Horizonte, Brazil. Electronic address: guilhermefagundesn@hotmail.com.
Helena DuaniInternal Medicine Department. University Hospital, Universidade Federal de Minas Gerais. Av. Prof Alfredo Balena, 110, Belo Horizonte, Brazil. Electronic address: hduani@yahoo.com.br.
Heloisa Reniers ViannaHospital Universitário Ciências Médicas, Belo Horizonte, Brazil. Electronic address: hrvianna@hotmail.com.
Henrique Cerqueira GuimarãesHospital Risoleta Tolentino Neves. Rua das Gabirobas, 01, Belo Horizonte, Brazil. Electronic address: hcerqueirag@gmail.com.
Jamille Hemétrio Salles Martins CostaHospital Márcio Cunha, Ipatinga, Brazil. Electronic address: jamillesalles@yahoo.com.br.
Joanna d'Arc Lyra BatistaHospital Regional do Oeste, Chapecó, Santa Catarina, Brazil. Electronic address: joannalyra@gmail.com.
Joice Coutinho de AlvarengaHospital João XXIII. Av. Professor Alfredo Balena, 400, Belo Horizonte, Brazil. Electronic address: joice-alvarenga@hotmail.com.
José Miguel ChatkinPneumology Department, Medical School, Universidade Católica do Rio Grande do Sul (RGS), Porto Alegre, Brazil. Hospital São Lucas PUCRS, Porto Alegre, Brazil. Electronic address: jmchatkin@pucrs.br.
Júlia Drumond Parreiras de MoraisHospital Universitário Ciências Médicas, Belo Horizonte, Brazil. Electronic address: juliadrumond_@hotmail.com.
Juliana Machado-RugoloHospital das Clínicas da Faculdade de Medicina de Botucatu. Botucatu, Brazil. Electronic address: jr.machado@unesp.br.
Karen Brasil RuschelHospital Mãe de Deus, Hospital Universitário de Canoas, Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ), Porto Alegre, Brasil. Electronic address: karenbruschel@gmail.com.
Lílian Santos PinheiroUniversidade Federal dos Vales do Jequitinhonha e Mucuri. R. Cruzeiro, 1, Teófilo Otoni, Brazil. Electronic address: lilian.pinheiro98@hotmail.com.
Luanna Silva Monteiro MenezesHospital Luxemburgo, Belo Horizonte, Brazil. Electronic address: luannasmonteiro@gmail.com.
Luciana Siuves Ferreira CoutoHospital Luxemburgo, Belo Horizonte, Brazil. Electronic address: lucianasiuves@gmail.com.
Luciane KopittkeHospital Nossa Senhora da Conceição. Av. Francisco Trein, 326, Porto Alegre, Brazil. Electronic address: kluciane@ghc.com.br.
Luís César de CastroHospital Bruno Born. Av. Benjamin Constant, 881, Lajeado, Brazil. Electronic address: pharmlucamsc@gmail.com.
Luiz Antônio NasiHospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: lnasi@terra.com.br.
Máderson Alvares de Souza CabralUniversidade Federal de Minas Gerais. Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil. Electronic address: madersonalvares@hotmail.com.
Maiara Anschau FlorianiHospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: maiara.floriani@hmv.org.br.
Maíra Dias SouzaHospital Metropolitano Odilon Behrens, Belo Horizonte, Brazil. Electronic address: mairadiassouza@gmail.com.
Marcelo CarneiroHospital Santa Cruz, Santa Cruz do Sul, Brazil. Electronic address: marceloc@unisc.br.
Maria Aparecida Camargos BicalhoHospital Julia Kubitschek. Avenida Professor Alfredo Balena 190, Belo Horizonte, Brazil. Electronic address: macbicalho@gmail.com.
Mariana Frizzo de GodoyHospital São Lucas PUCRS, Porto Alegre, Brazil. Electronic address: mfdegodoy@gmail.com.
Matheus Carvalho Alves NogueiraHospitais da Rede Mater Dei, Belo Horizonte, Brazil. Electronic address: mathnogueira42@gmail.com.
Milton Henriques Guimarães JúniorHospital Márcio Cunha, Ipatinga, Brazil. Electronic address: miltonhenriques@yahoo.com.br.
Natália da Cunha Severino SampaioHospital Eduardo de Menezes. R. Dr. Cristiano Rezende, 2213, Belo Horizonte, Brazil. Electronic address: natsamster@gmail.com.
Neimy Ramos de OliveiraHospital Eduardo de Menezes. R. Dr. Cristiano Rezende, 2213, Belo Horizonte, Brazil. Electronic address: neimyramos@gmail.com.
Pedro Ledic AssafHospital Metropolitano Doutor Célio de Castro. Rua Dona Luiza, 311, Belo Horizonte, Brazil. Electronic address: pedro.ledic@hmdcc.com.br.
Renan Goulart FingerHospital Regional do Oeste, Chapecó, Santa Catarina, Brazil. Electronic address: renanfinger@yahoo.com.br.
Roberta Xavier CamposHospital Julia Kubitschek. Avenida Professor Alfredo Balena 190, Belo Horizonte, Brazil. Electronic address: xaviercampos.roberta@gmail.com.
Rochele Mosmann MenezesHospital Santa Cruz, Santa Cruz do Sul, Brazil. Electronic address: rochelemenezes@unisc.br.
Saionara Cristina FranciscoHospital Metropolitano Doutor Célio de Castro. Rua Dona Luiza, 311, Belo Horizonte, Brazil. Electronic address: saionaracf@gmail.com.
Samuel Penchel AlvarengaHospital São João de Deus, Divinópolis, Brazil. Electronic address: samuelpenchel@gmail.com.
Silvana Mangeon Mereilles GuimarãesHospital Semper. Alameda Ezequiel Dias, 389, Belo Horizonte, Brazil. Electronic address: smangeon@gmail.com.
Silvia Ferreira AraújoHospital Semper. Alameda Ezequiel Dias, 389, Belo Horizonte, Brazil. Electronic address: silviaferreiragastro@gmail.com.
Talita Fischer OliveiraHospital Metropolitano Odilon Behrens, Belo Horizonte, Brazil. Electronic address: talitafischeroliveira@gmail.com.
Thulio Henrique Oliveira DinizHospital São João de Deus, Divinópolis, Brazil. Electronic address: thuliodinizmed@gmail.com.
Yuri Carlotto RamiresHospital Bruno Born. Av. Benjamin Constant, 881, Lajeado, Brazil. Electronic address: yuri.ramires@gmail.com.
Evelin Paola de Almeida CenciHospital Universitário Canoas, Canoas, Rio Grande do Sul, Brazil. Electronic address: assistencial6_hu@centrodepesquisaclinica.com.br.
Thainara Conceição de OliveiraHospital Universitário Canoas, Canoas, Rio Grande do Sul, Brazil. Electronic address: thainarastaehler@hotmail.com.
Alexandre Vargas SchwarzboldHospital Universitário de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. Electronic address: alexvspoa@gmail.com.
Patricia Klarmann ZiegelmannHospital Tacchini, Bento Gonçalves, Brazil. Electronic address: patriciakz99@gmail.com.
Roberta PozzaHospital Tacchini, Bento Gonçalves, Brazil. Electronic address: robertapozza@tacchini.com.br.
Caroline Scherer CarvalhoHospital Universitário de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. Electronic address: dra.carolscherer@gmail.com.
Magda Carvalho PiresDepartment of Statistics, Universidade Federal de Minas Gerais. Av. Presidente Antônio Carlos, 6627, ICEx, sala 4071, Belo Horizonte, Brazil. Electronic address: magda@est.ufmg.br.
Milena Soriano MarcolinoDepartment of Internal Medicine, Medical School; and Telehealth Center, University Hospital, Universidade Federal de Minas Gerais. Avenida Professor Alfredo Balena 190 sala 246, Belo Horizonte, Brazil; Institute for Health Technology Assessment (IATS/ CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507, Porto Alegre, Brazil. Electronic address: milenamarc@ufmg.br.
Universidade Federal de Minas Gerais · BRFundação Hospitalar do Estado de Minas Gerais · BRHospital Metropolitano · ECFaculdade de Ciências Médicas de Minas Gerais · BRUniversidade Federal do Rio Grande do Sul · BRCentro Universitário de Belo Horizonte · BREzequiel Dias Foundation · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital Moinhos de Vento · BRHospital Nossa Senhora da Conceição · BRHospital Risoleta Tolentino Neves · BRHospital São Lucas da PUCRS · BRHospital Universitário de Santa Maria · BRInstituto Benjamin Constant · BRLaboratório Bacchi · BRMater Dei Hospital · BRUniversidade de Santa Cruz do Sul · BRUniversidade La Salle · BRYahoo (Spain) · ESFederal University of São João del-Rei · BR
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.
methodsThe study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis.
resultsOf 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062).
conclusionPatients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.
Indexed as
COVID-19HypothyroidismAgedCOVID-19 TestingFemaleHospital MortalityHumansPrognosisRegistriesSARS-CoV-2COVID-19EpidemiologyHypothyroidismMortalityPrognosis
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