ArticleAdvanced materials (Deerfield Beach, Fla.)2022
Jammed Micro-Flake Hydrogel for Four-Dimensional Living Cell Bioprinting.
Article in Advanced materials (Deerfield Beach, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Advanced cell-instructive bio-inks: Engineering multiscale niches for functional tissue formation.Bioactive materials · 2027Review
- 3D printable tough hydrogel actuators.Materials horizons · 2026Review
- Review
- Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Discrete 2D Material Programming for 3D Shaping and Morphogenesis-Inspired 4D Bioprinting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reprogrammable 4D tissue engineering hydrogel scaffold via reversible ion printing.Bioactive materials · 2026Article
- Microgel-Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function.Advanced healthcare materials · 2026Review
- Exploring cartilage development and disease models: applications of cartilage organoids.Inflammation and regeneration · 2026Review
- In Situ Programming of Shape-Morphing Hydrogels via Vat Photopolymerization for 4D Bioprinting.Gels (Basel, Switzerland) · 2026Article
- 4D Printing in Biomedical Implants and Functional Healthcare Devices.Journal of functional biomaterials · 2026Review
- Clickable Microgel Inks Enable Spatioselective, Multi-Stimuli Programmable Assembly of Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Self-Oscillating Helix Showing Amplified Winding and Unwinding Motions.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Alginate-Based Hydrogels: Recent Progress in Preparation, Property Tuning, and Multifunctional Applications.Gels (Basel, Switzerland) · 2026Review
- Advances in 3D Printed Scaffolds for Periodontal Regeneration.Current oral health reports · 2026Review
- Dynamic Regulation of Granular Hydrogels Through Guest-Host Interactions to Spatiotemporally Guide Cellular Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanoconfined entanglement-enhanced phase separation enables tough and contractile ionogel fibers.Nature communications · 2025Article
- Cell Contractile Force-Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multiscale Structure-Property Relationships in Gelatin-Based Granular Hydrogel Scaffolds.ACS macro letters · 2025Article
- Facile Single-Nanocomposite 4D Bioprinting of Dynamic Hydrogel Constructs with Thickness-Controlled Gradient.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments.Advanced healthcare materials · 2025Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
4D bioprinting is promising to build cell-laden constructs (bioconstructs) with complex geometries and functions for tissue/organ regeneration applications. The development of hydrogel-based 4D bioinks, especially those allowing living cell printing, with easy preparation, defined composition, and controlled physical properties is critically important for 4D bioprinting. Here, a single-component jammed micro-flake hydrogel (MFH) system with heterogeneous size distribution, which differs from the conventional granular microgel, has been developed as a new cell-laden bioink for 4D bioprinting. This jammed cytocompatible MFH features scalable production and straightforward composition with shear-thinning, shear-yielding, and rapid self-healing properties. As such, it can be smoothly printed into stable 3D bioconstructs, which can be further cross-linked to form a gradient in cross-linking density when a photoinitiator and a UV absorber are incorporated. After being subject to shape morphing, a variety of complex bioconstructs with well-defined configurations and high cell viability are obtained. Based on this system, 4D cartilage-like tissue formation is demonstrated as a proof-of-concept. The establishment of this versatile new 4D bioink system may open up a number of applications in tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.