Evidence map›Paper›PMID 35064941›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2022

Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in Cancellous Bone From Men With Type 2 Diabetes Mellitus.

Sara E Sacher, Heather B Hunt, Sashank Lekkala, Kelsie A Lopez, Jesse Potts, Alison K Heilbronner, Emily M Stein, Christopher J Hernandez, Eve Donnelly

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sara E SacherDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-8410-1500
Heather B HuntDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
Sashank LekkalaDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
Kelsie A LopezDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
Jesse PottsDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
Alison K HeilbronnerDepartment of Medicine, Endocrinology and Metabolic Bone Service, Hospital for Special Surgery, New York, NY, USA.
Emily M SteinDepartment of Medicine, Endocrinology and Metabolic Bone Service, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0002-1463-5774
Christopher J HernandezResearch Division, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0002-0712-6533
Eve DonnellyDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-8165-9568
Cornell University · USHospital for Special Surgery · US

Funding

The Microbiome and Bone StrengthR01AG067997 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, CHRISTOPHER JOHN · 2021 to 2025
$3.2M
Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic boneK01AR064314 · NIAMS · CORNELL UNIVERSITY · PI DONNELLY, EVE · 2013 to 2017
$659k
The Role of Bone Resorption in Bone Marrow LesionsR21AR073454 · NIAMS · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2018 to 2019
$407k
NIAMS NIH HHS K01 AR064314NIAMS NIH HHS R21 AR073454NIA NIH HHS R01 AG067997
6 · The paper itself

Abstract

Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fracture despite exhibiting normal to high bone mineral density (BMD). Conditions arising from T2DM, such as reduced bone turnover and alterations in microarchitecture, may contribute to skeletal fragility by influencing bone morphology and microdamage accumulation. The objectives of this study were (i) to characterize the effect of T2DM on microdamage quantity and morphology in cancellous bone, and (ii) relate the accumulation of microdamage to the cancellous microarchitecture. Cancellous specimens from the femoral neck were collected during total hip arthroplasty (T2DM: n = 22, age = 65 ± 9 years, glycated hemoglobin [HbA1c] = 7.00% ± 0.98%; non-diabetic [non-DM]: n = 25, age = 61 ± 8 years, HbA1c = 5.50% ± 0.4%), compressed to 3% strain, stained with lead uranyl acetate to isolate microdamage, and scanned with micro-computed tomography (μCT). Individual trabeculae segmentation was used to isolate rod-like and plate-like trabeculae and their orientations with respect to the loading axis. The T2DM group trended toward a greater BV/TV (+27%, p = 0.07) and had a more plate-like trabecular architecture (+8% BV

Indexed as

Cancellous BoneDiabetes Mellitus, Type 2AgedBone DensityFemur NeckGlycated HemoglobinHumansMaleMiddle AgedX-Ray MicrotomographyGlycated HemoglobinBIOMECHANICSBONE MATRIXBONE μCTDISEASES OF BONE - OTHER (TYPE 2 DIABETES)MATRIX MINERALIZATION

Identifiers

PMID35064941
PMCPMC9833494
OpenAlexW4207067073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.