Evidence map›Paper›PMID 35064921›Full record

ArticlePharmacological reports : PR2022

Allosteric modulation of dopamine D

Justyna Żuk, Damian Bartuzi, Andrea G Silva, Monika Pitucha, Oliwia Koszła, Tomasz M Wróbel, Dariusz Matosiuk, Marián Castro, Agnieszka A Kaczor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Allosteric Modulators of Dopamine DMolecules (Basel, Switzerland) · 2022
    Review
  3. The Role of Lipids in Allosteric Modulation of Dopamine DMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Justyna ŻukDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., 20093, Lublin, Poland.
Damian BartuziDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., 20093, Lublin, Poland.
Andrea G SilvaDepartment of Pharmacology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Avda de Barcelona, 15782, Santiago de Compostela, Spain.
Monika PituchaIndependent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., 20093, Lublin, Poland.
Oliwia KoszłaDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., 20093, Lublin, Poland.
Tomasz M WróbelDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., 20093, Lublin, Poland.
Dariusz MatosiukDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., 20093, Lublin, Poland.
Marián CastroDepartment of Pharmacology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Avda de Barcelona, 15782, Santiago de Compostela, Spain.
Agnieszka A KaczorDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki St., 20093, Lublin, Poland. agnieszka.kaczor@umlub.pl.ORCID http://orcid.org/0000-0001-8679-9623

Funding

Ministerio de Ciencia, Innovación y Universidades PID2020-119754GB-I00Narodowe Centrum Nauki 2017/27/B/NZ7/01767
6 · The paper itself

Abstract

backgroundAllosteric modulation of G protein-coupled receptors (GPCRs) is nowadays one of the hot topics in drug discovery. In particular, allosteric modulators of D

methodsTo address some subtle structural and stereochemical aspects of allosteric modulation of D

resultsOur molecular dynamics simulations confirmed literature reports that the R enantiomer of compound 1 is a positive allosteric modulator of the D

conclusionsOur work reveals that allosteric modulation of the D

Indexed as

DopamineMolecular Dynamics SimulationAllosteric RegulationBinding SitesLigandsReceptors, G-Protein-CoupledDopamineLigandsReceptors, G-Protein-CoupledDopamine D2 receptorGPCRsMolecular dynamicsMolecular switchesNegative allosteric modulatorsPositive allosteric modulators

Identifiers

PMID35064921
PMCPMC8964653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.