ArticleEuropean radiology2022
Quantitative susceptibility mapping reveals brain iron deficiency in children with attention-deficit/hyperactivity disorder: a whole-brain analysis.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Quantitative susceptibility mapping in pediatric neuroimaging: a systematic review of applications and advancements.Pediatric radiology · 2026Pooled it
- Quantitative susceptibility mapping reveals abnormal iron reduction in deep gray matter of children with global developmental delay.Pediatric radiology · 2026Article
- Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review.Human brain mapping · 2026Review
- IronDeficiency Across Neurodevelopmental Disorders: Comparative Insights from ADHD and Autism Spectrum Disorder.Children (Basel, Switzerland) · 2026Review
- Investigation of quantitative synthetic MRI in the evaluation of attention-deficit/hyperactivity disorder.Quantitative imaging in medicine and surgery · 2026Article
- Quantitative susceptibility mapping of brain iron in adult ADHD.Frontiers in psychiatry · 2026Article
- Quantitative susceptibility mapping at 7T as a biomarker of post- and interictal extravascular iron in patients with focal epilepsy.EBioMedicine · 2025Article
- Quantitative susceptibility mapping shows alterations of brain iron content in children with autism spectrum disorder: a whole-brain analysis.BMC psychiatry · 2025Article
- Brain iron deficiency in children with attention deficit hyperactivity disorder using iterAtive magnetic suscePtibility sources sepARaTion (APART-QSM).Quantitative imaging in medicine and surgery · 2025Article
- Increased cortical iron deposition in glioma patients: a quantitative susceptibility mapping study.Journal of neuro-oncology · 2025Article
- Quantitative susceptibility mapping study of deep gray matter iron content in glioma patients.Quantitative imaging in medicine and surgery · 2025Article
- Brain Iron Alteration in Pediatric Tourette Syndrome: A Quantitative Susceptibility Mapping Study.European journal of neurology · 2025Article
- Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study.Translational psychiatry · 2025Article
- The impact of trans fatty acids on ADHD in relation to the gut microbiome.Frontiers in nutrition · 2025Review
- Abnormality in Peripheral and Brain Iron Contents and the Relationship with Grey Matter Volumes in Major Depressive Disorder.Nutrients · 2024Article
- Quantitative susceptibility mapping shows lower brain iron content in children with childhood epilepsy with centrotemporal spikes.Japanese journal of radiology · 2023Article
- Brain Iron Homeostasis and Mental Disorders.Antioxidants (Basel, Switzerland) · 2023Review
- Association of Maternal and Child Anemia With Brain Structure in Early Life in South Africa.JAMA network open · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo quantitatively measure and compare the whole-brain iron deposition between attention-deficit/hyperactivity disorder (ADHD) patients and typically developing (TD) children using the quantitative susceptibility mapping (QSM) technique.
methodsThis study was approved by the institutional review board of our institution (No. [2019]328). Fifty-one patients between 6 and 14 years with clinical diagnosis of ADHD and 51 age- and gender-paired TD children were enrolled. For each participant, the 3D T1 and multi-echo GRE sequence were performed to acquire the whole-brain data with 3.0-T MRI. The QSM maps were calculated using STISuite toolbox. After normalizing the QSM images to MNI space, the voxel-based analysis was used to compare the iron content between the two groups. Pearson's correlation test was used to assess the associations between the iron content and the score of the tablet-PC-based cancellation test, which was done to evaluate the attention concentration level.
resultsIron deficiency was observed in several brain regions in children with ADHD, including bilateral striatums, anterior cingulum, olfactory gyrus, and right lingual gyri. In further correlation analysis, the left anterior cingulum was found to show positive correlation with the symptom severity (r = 0.326, p < 0.05).
conclusionsOur study demonstrated that the iron deficiency in several brain regions might be related with ADHD, which might be valuable for further studies. And QSM might have the potential efficacy in the auxiliary diagnosis of ADHD. KEY POINTS: • Iron deficiency was observed in several brain regions in children with ADHD, which include bilateral striatums, the critical regions in the dopaminergic transmitter system. • The iron content in the left ACG may have association with the symptom severity of ADHD. • QSM might have the potential efficacy in the auxiliary diagnosis of ADHD.
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