ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro-Organ Signals.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 58 citations in OpenAlex.
- Miniaturization of Aptasensors in Organic Electrochemical Transistors for Sensitivity Enhancement.Analytical chemistry · 2026Article
- Pancreatic α cells are required for nutrient homeostasis by regulating dynamic β cell networks in islets.Science advances · 2026Article
- Precision Channel Engineering of Nanotube-Embedded Organic Electrochemical Transistors for Ultrasensitive Neurofilament Light Chain Detection.ACS applied bio materials · 2026Article
- Choline Ionic Liquid for Long-Term Stable Organic Electrochemical Transistors.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Organic Electrochemical Transistors Monolithically Integrated with Precise Micro-Dispensing Enable High-Performance Biosignals Amplification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Additive Manufacturing of Organic Electrochemical Transistors: Methods, Device Architectures, and Emerging Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- In Situ Functionalization of Polar Polythiophene-Based Organic Electrochemical Transistor to Interface In Vitro Models.ACS applied materials & interfaces · 2024Article
- Advanced Neuromorphic Applications Enabled by Synaptic Ion-Gating Vertical Transistors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Vertical organic electrochemical transistor platforms for efficient electropolymerization of thiophene based oligomers.Journal of materials chemistry. C · 2024Article
- Monolithically integrated high-density vertical organic electrochemical transistor arrays and complementary circuits.Nature electronics · 2024Article
- Active Micro-Nano-Collaborative Bioelectronic Device for Advanced Electrophysiological Recording.Nano-micro letters · 2024Review
- Extracellular electrophysiology on clonal human β-cell spheroids.Frontiers in endocrinology · 2024Article
- Progress in Data Acquisition of Wearable Sensors.Biosensors · 2022Review
- Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro-Organ Signals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Electrical signals are fundamental to key biological events such as brain activity, heartbeat, or vital hormone secretion. Their capture and analysis provide insight into cell or organ physiology and a number of bioelectronic medical devices aim to improve signal acquisition. Organic electrochemical transistors (OECT) have proven their capacity to capture neuronal and cardiac signals with high fidelity and amplification. Vertical PEDOT:PSS-based OECTs (vOECTs) further enhance signal amplification and device density but have not been characterized in biological applications. An electronic board with individually tuneable transistor biases overcomes fabrication induced heterogeneity in device metrics and allows quantitative biological experiments. Careful exploration of vOECT electric parameters defines voltage biases compatible with reliable transistor function in biological experiments and provides useful maximal transconductance values without influencing cellular signal generation or propagation. This permits successful application in monitoring micro-organs of prime importance in diabetes, the endocrine pancreatic islets, which are known for their far smaller signal amplitudes as compared to neurons or heart cells. Moreover, vOECTs capture their single-cell action potentials and multicellular slow potentials reflecting micro-organ organizations as well as their modulation by the physiological stimulator glucose. This opens the possibility to use OECTs in new biomedical fields well beyond their classical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.