Evidence map›Paper›PMID 35064773›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

A Guanosine-Quadruplex Hydrogel as Cascade Reaction Container Consuming Endogenous Glucose for Infected Wound Treatment-A Study in Diabetic Mice.

Yuanfeng Li, Linzhu Su, Yongxin Zhang, Yong Liu, Fan Huang, Yijin Ren, Yingli An, Linqi Shi, Henny C van der Mei, Henk J Busscher

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  5. CuChemistry, an Asian journal · 2026
    Article
  6. Cu single-atom embedded g-CNature communications · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuanfeng LiState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, P. R. China.
Linzhu SuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, P. R. China.
Yongxin ZhangState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, P. R. China.
Yong LiuWenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), 1 Jinlian Road, Longwan District, Wenzhou, 325001, P. R. China.ORCID 0000-0003-1738-7857
Fan HuangTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 238 Baiti Road, Tianjin, 300192, P. R. China.
Yijin RenUniversity of Groningen and University Medical Center Groningen, Department of Orthodontics, Hanzeplein 1, Groningen, 9700 RB, The Netherlands.
Yingli AnState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, P. R. China.
Linqi ShiState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, P. R. China.ORCID 0000-0002-9534-795X
Henny C van der MeiUniversity of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands.
Henk J BusscherUniversity of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands.

Funding

National Natural Science Foundation of China 21620102005National Natural Science Foundation of China 51933006National Natural Science Foundation of China 52003184Startup Funding of Wenzhou Institution, University of Chinese Academy of Sciences WIUCASQD2021022
6 · The paper itself

Abstract

Diabetic foot ulcers infected with antibiotic-resistant bacteria form a severe complication of diabetes. Antimicrobial-loaded hydrogels are used as a dressing for infected wounds, but the ongoing rise in the number of antimicrobial-resistant infections necessitates new, nonantibiotic based designs. Here, a guanosine-quadruplex (G

Indexed as

Diabetes Mellitus, ExperimentalWound InfectionAnimalsGlucoseGuanosineHumansHydrogelsMiceGlucoseGuanosineHydrogelsbacterial infectioncascade reactionsdiabetic foot ulcersreactive-oxygen-speciessupramolecular hydrogels

Identifiers

PMID35064773
PMCPMC8895150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.