ArticleSchizophrenia bulletin2022
Dimensions of Formal Thought Disorder and Their Relation to Gray- and White Matter Brain Structure in Affective and Psychotic Disorders.
Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Voice Patterns as Markers of Schizophrenia: Building a Cumulative Generalizable Approach Via a Cross-Linguistic and Meta-analysis Based Investigation.Schizophrenia bulletin · 2023Pooled it
- What Static Connectivity Misses: Dynamic Alpha-Band Brain Network States in First-Episode Psychosis.Brain topography · 2026Article
- Schizophrenia, variability, and the Anna Karenina principle.Psychiatry research. Neuroimaging · 2026Article
- Structural neuroimaging correlates of semantic incoherence in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Gesture Impairments in Schizophrenia: Distinct Roles of Negative Symptoms and Formal Thought Disorder.Schizophrenia bulletin · 2026Article
- Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort.Schizophrenia bulletin · 2026Article
- Linking speech patterns to brain structure in affective and psychotic disorders: an integrative natural language processing approach.Molecular psychiatry · 2026Article
- Disorganisation and depression: a re-examination of how we think and speak when depressed.European archives of psychiatry and clinical neuroscience · 2026Review
- Clinical psychopathology-based early relapse prediction model using speech and language in psychosis.Schizophrenia research. Cognition · 2026Review
- Linking spontaneous speech, cognition, and psychopathology across affective and psychotic disorders: A network approach.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Transdiagnostic types of formal thought disorder and their association with gray matter brain structure: a model-based cluster analytic approach.Molecular psychiatry · 2025Article
- Genome-wide analysis identifies novel shared loci between depression and white matter microstructure.Molecular psychiatry · 2025Article
- Differential structural cortical correlates of positive, negative, and linguistic control formal thought disorder dimensions in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Brain structural associations of syntactic complexity and diversity across schizophrenia spectrum and major depressive disorders, and healthy controls.Schizophrenia (Heidelberg, Germany) · 2024Article
- Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset.Molecular psychiatry · 2024Article
- Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample.Translational psychiatry · 2024Article
- A Systematic Evaluation of Machine Learning-Based Biomarkers for Major Depressive Disorder.JAMA psychiatry · 2024Article
- The Neurobiology of Formal Thought Disorder.Current topics in medicinal chemistry · 2024Review
Corrections and comments
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Authors and funding
23 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Factorial dimensions and neurobiological underpinnings of formal thought disorders (FTD) have been extensively investigated in schizophrenia spectrum disorders (SSD). However, FTD are also highly prevalent in other disorders. Still, there is a lack of knowledge about transdiagnostic, structural brain correlates of FTD. In N = 1071 patients suffering from DSM-IV major depressive disorder, bipolar disorder, or SSD, we calculated a psychopathological factor model of FTD based on the SAPS and SANS scales. We tested the association of FTD dimensions with 3 T MRI measured gray matter volume (GMV) and white matter fractional anisotropy (FA) using regression and interaction models in SPM12. We performed post hoc confirmatory analyses in diagnostically equally distributed, age- and sex-matched sub-samples to test whether results were driven by diagnostic categories. Cross-validation (explorative and confirmatory) factor analyses revealed three psychopathological FTD factors: disorganization, emptiness, and incoherence. Disorganization was negatively correlated with a GMV cluster comprising parts of the middle occipital and angular gyri and positively with FA in the right posterior cingulum bundle and inferior longitudinal fascicle. Emptiness was negatively associated with left hippocampus and thalamus GMV. Incoherence was negatively associated with FA in bilateral anterior thalamic radiation, and positively with the hippocampal part of the right cingulum bundle. None of the gray or white matter associations interacted with diagnosis. Our results provide a refined mapping of cross-disorder FTD phenotype dimensions. For the first time, we demonstrated that their neuroanatomical signatures are associated with language-related gray and white matter structures independent of diagnosis.
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