Evidence map›Paper›PMID 35064611›Full record

ArticlePhytochemical analysis : PCA2022

Detailed investigation of the composition and transformations of phenolic compounds in fresh and fermented Vaccinium floribundum berry extracts by high-resolution mass spectrometry and bioinformatics.

Andrea Cerrato, Susy Piovesana, Sara Elsa Aita, Chiara Cavaliere, Simona Felletti, Aldo Laganà, Carmela Maria Montone, Celia Vargas-de-la-Cruz, Anna Laura Capriotti

Open access · hybridAbstract read
In one paragraph

Article in Phytochemical analysis : PCA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Polyphenolic Compounds from Andean Berry (Foods (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Berries fromPlants (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Fermentation ofNutrients · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Andrea CerratoDepartment of Chemistry, Sapienza University of Rome, Rome, Italy.
Susy PiovesanaDepartment of Chemistry, Sapienza University of Rome, Rome, Italy.
Sara Elsa AitaDepartment of Chemistry, Sapienza University of Rome, Rome, Italy.
Chiara CavaliereDepartment of Chemistry, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0003-1332-682X
Simona FellettiDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Aldo LaganàDepartment of Chemistry, Sapienza University of Rome, Rome, Italy.
Carmela Maria MontoneDepartment of Chemistry, Sapienza University of Rome, Rome, Italy.
Celia Vargas-de-la-CruzFaculty of Pharmacy and Biochemistry, Academic Department Pharmacology, Toxicology and Bromatology, Centro Latinoamericano de Enseñanza e Investigación en Bacteriología Alimentaria-CLEIBA, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Anna Laura CapriottiDepartment of Chemistry, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITNational University of San Marcos · PEUniversity of Ferrara · ITUniversity of Salento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBlueberries are known for their very high content of biologically active phenolic compounds; nonetheless, differently from the North American and European species of blueberries, Neotropical blueberries have not been extensively studied yet.

objectivesIn the present paper, the phenolic composition of Vaccinium floribundum Kunth, which is endemic to the Andean regions and grows 1,600 to 4,500 meters above sea level, was investigated by ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS). Native and fermented berries were compared in terms of phenolic composition as well as antioxidant activity, total phenolic content, and total anthocyanin content. MATERIALS AND

methodsV. floribundum native and fermented berries were extracted and analyzed by UHPLC-HRMS. The acquired datasets were processed by Compound Discoverer 3.1 using a dedicated data analysis workflow that was specifically set up for phenolic compound identification.

resultsIn total, 309 compounds were tentatively identified, including anthocyanins, flavonoids, phenolic acids, and proanthocyanidins. The molecular transformations of phenolic compounds during fermentation were comprehensively investigated for the first time, and by a customized data processing workflow, 13 quinones and quinone methides were tentatively identified in the fermented samples. Compared to other species of the genus Vaccinium, a peculiar phenolic profile is observed, with low abundance of highly methylated compounds.

conclusionAndean berries are a rich source of a wide variety of phenolic compounds. Untargeted MS analyses coupled to a dedicated data processing workflow allowed expanding the current knowledge on these berries, improving our understanding of the fate of phenolic compounds after fermentation.

Indexed as

VacciniumAnthocyaninsAntioxidantsChromatography, High Pressure LiquidComputational BiologyFruitMass SpectrometryPhenolsPlant ExtractsAnthocyaninsAntioxidantsPhenolsPlant ExtractsblueberryCompound Discovererhigh-resolution mass spectrometryNeotropical berriespolyphenolsquercetin quinone

Identifiers

PMID35064611
PMCPMC9543071
OpenAlexW4207005505

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.