ArticleMedical physics2022
Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry.
Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 92 citations in OpenAlex.
- Evaluation of a Faraday cup-style detector as a beam diagnostic system for ultra-high dose rate (FLASH) electron beams.Journal of applied clinical medical physics · 2026Article
- Reduced corneal toxicity following whole brain irradiation in mice.Clinical and translational radiation oncology · 2026Article
- Antitumor Activity of Combined Topoisomerase Inhibition and FLASH Radiotherapy in Head and Neck Carcinoma Biomodels.MedComm · 2026Article
- Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.Medical physics · 2026Article
- One-year follow-up after fractionated ultra-high-dose-rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum.Precision radiation oncology · 2026Article
- Development and application ofPhysics and imaging in radiation oncology · 2026Article
- Small dose monitor based on silicon-carbide diodes for FLASH radiotherapy.Medical physics · 2026Article
- Plaque-adaptive flexible film dosimetry system for Ru-106 plaque brachytherapy commissioning and quality assurance.Medical physics · 2026Article
- FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy.BMC medicine · 2026Article
- First experimental characterization of a low-pressure nitrogen filled parallel-plate ionization chamber for UHDP electron beam dosimetry.Medical physics · 2026Article
- Using hydrated electron temporal measurement as dosimetry of individual electron FLASH beam pulses.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026Article
- InAlN/GaN Detectors for Real-Time Dosimetry in Ultra-High Dose Rate FLASH Radiotherapy.IEEE sensors letters · 2026Article
- Early molecular changes induced by FLASH irradiation in MCF10A and MDA-MB-231 breast cell lines.Frontiers in oncology · 2026Article
- The Potential of Dosimetry and the Visualization of Microbeam Arrays in NIPAM Gel at the PETRA III Synchrotron.Gels (Basel, Switzerland) · 2025Article
- Quality assurance and reporting for FLASH clinical trials: The experience of the FEATHER trial.Medical physics · 2025Article
- Characterizing diamond detectors for various dose and dose rate measurements in scanned carbon and oxygen beams.Medical physics · 2025Article
- Characterization of silicon carbide diodes as cost-effective active detectors for proton UHDR dosimetry.Medical physics · 2025Article
- Evaluation of the two-voltage method for parallel-plate ionization chambers irradiated with pulsed beams.Medical physics · 2025Article
- Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects.World journal of radiology · 2025Review
- A 2D detector array for relative dosimetry and beam steering for FLASH radiotherapy with electrons.Medical physics · 2025Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeFLASH radiotherapy (RT) is an emerging technique in which beams with ultra-high dose rates (UH-DR) and dose per pulse (UH-DPP) are used. Commercially available active real-time dosimeters have been shown to be unsuitable in such conditions, due to severe response nonlinearities. In the present study, a novel diamond-based Schottky diode detector was specifically designed and realized to match the stringent requirements of FLASH-RT.
methodsA systematic investigation of the main features affecting the diamond response in UH-DPP conditions was carried out. Several diamond Schottky diode detector prototypes with different layouts were produced at Rome Tor Vergata University in cooperation with PTW-Freiburg. Such devices were tested under electron UH-DPP beams. The linearity of the prototypes was investigated up to DPPs of about 26 Gy/pulse and dose rates of approximately 1 kGy/s. In addition, percentage depth dose (PDD) measurements were performed in different irradiation conditions. Radiochromic films were used for reference dosimetry.
resultsThe response linearity of the diamond prototypes was shown to be strongly affected by the size of their active volume as well as by their series resistance. By properly tuning the design layout, the detector response was found to be linear up to at least 20 Gy/pulse, well into the UH-DPP range conditions. PDD measurements were performed by three different linac applicators, characterized by DPP values at the point of maximum dose of 3.5, 17.2, and 20.6 Gy/pulse, respectively. The very good superimposition of three curves confirmed the diamond response linearity. It is worth mentioning that UH-DPP irradiation conditions may lead to instantaneous detector currents as high as several mA, thus possibly exceeding the electrometer specifications. This issue was properly addressed in the case of the PTW UNIDOS electrometers.
conclusionsThe results of the present study clearly demonstrate the feasibility of a diamond detector for FLASH-RT applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.