Evidence map›Paper›PMID 35064559›Full record

ArticleCardiovascular engineering and technology2022

Experimental and Mouse-Specific Computational Models of the Fbln4

Marisa S Bazzi, Ramin Balouchzadeh, Shawn N Pavey, James D Quirk, Hiromi Yanagisawa, Vijay Vedula, Jessica E Wagenseil, Victor H Barocas

Abstract read
In one paragraph

Article in Cardiovascular engineering and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Ascending aortic aneurysm growth in the Fbln4Biomechanics and modeling in mechanobiology · 2025
    Article
  8. Inverse finite element identification of murine aortic material properties:Computer methods in biomechanics and biomedical engineering · 2025
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marisa S BazziDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA.
Ramin BalouchzadehDepartment of Mechanical Engineering & Materials Science, Washington University, St. Louis, MO, 63110, USA.
Shawn N PaveyDepartment of Mechanical Engineering & Materials Science, Washington University, St. Louis, MO, 63110, USA.
James D QuirkMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Hiromi YanagisawaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan.
Vijay VedulaDepartment of Mechanical Engineering, Columbia University, New York, NY, 10027, USA.
Jessica E WagenseilDepartment of Mechanical Engineering & Materials Science, Washington University, St. Louis, MO, 63110, USA.
Victor H BarocasDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA. baroc001@umn.edu.

Funding

Multiscale Model of Ascending Thoracic Aortic AneurysmU01HL139471 · NHLBI · UNIVERSITY OF MINNESOTA · PI BAROCAS, VICTOR H · 2018 to 2021
$1.6M
NHLBI NIH HHS U01 HL139471
6 · The paper itself

Abstract

purposeTo use computational methods to explore geometric, mechanical, and fluidic biomarkers that could correlate with mouse lifespan in the Fbln4

methodsImage-based, mouse-specific fluid-structure-interaction models were developed for Fbln4

resultsComparing the different geometrical and biofluidic biomarkers to the mouse lifespan, it was found that mean oscillatory shear index (OSI

conclusionThe results highlight potential biomarkers of ATAA outcomes that can be obtained through noninvasive imaging and computational simulations, and they illustrate the potential synergy between small-animal and computational models.

Indexed as

Aortic Aneurysm, ThoracicAnimalsBiomarkersComputer SimulationDisease Models, AnimalMiceModels, CardiovascularStress, MechanicalBiomarkersAneurysmBiomarkerBiomechanicsFluid–structure interaction

Identifiers

PMID35064559
PMCPMC9304450

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.