ArticleJournal of the Association for Research in Otolaryngology : JARO2022
Metabolic and Sensory Components of Age-Related Hearing Loss.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults.American journal of human genetics · 2026Article
- Structural and Molecular Evidence for a Frequency-Dependent Electrochemical Gradient in the Human Cochlear Lateral Wall.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Physiological, Histological, and Cognitive Characterization of a Rhesus Macaque Model of Presbycusis.bioRxiv : the preprint server for biology · 2026Article
- Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults from the CLSA.bioRxiv : the preprint server for biology · 2026Article
- Short tandem repeats significantly contribute to the genetic architecture of metabolic and sensory age-related hearing loss phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Insights Into Stria Vascular Function, Stria Immunity, and Age-Related Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025Review
- Large-scale audiometric phenotyping identifies distinct genes and pathways involved in hearing loss subtypes.Communications biology · 2025Article
- Non-invasive testing to diagnose the underlying auditory pathology of hearing impairment.Hearing research · 2025Article
- Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Review
- Relationship between TyG-related index and hearing loss in people over 45 s in China.Frontiers in public health · 2025Article
- Speech sound discrimination in background noise across the lifespan: a comparative study in Mongolian gerbils and humans.Frontiers in aging neuroscience · 2025Article
- Executive Function Associations With Audibility-Adjusted Speech Perception in Noise.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Polygenic Risk Score-Based Association Analysis Identifies Genetic Comorbidities Associated with Age-Related Hearing Difficulty in Two Independent Samples.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss.International journal of molecular sciences · 2024Review
- Age-Related Deficits in Binaural Hearing: Contribution of Peripheral and Central Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Age-related changes in the zebrafish and killifish inner ear and lateral line.Scientific reports · 2024Article
- Predicting Atrophy of the Cochlear Stria Vascularis from the Shape of the Threshold Audiogram.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss.PLoS genetics · 2023Article
- Reversal of an existing hearing loss by gene activation inProceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Age-related hearing loss is a multifactorial condition with effects of aging and environmental exposures that contribute to cochlear pathologies. Metabolic hearing loss involves declines in the endocochlear potential, which broadly reduce cochlear amplification of low-level sounds. Sensory hearing loss involves damage to outer hair cells that may eliminate amplification, especially for high-frequency sounds. A novel approach was developed to estimate the extent of metabolic and sensory components (in dB) for an individual, by combining hearing loss profiles to optimally approximate their hearing thresholds (audiogram). This approach was validated using estimates of metabolic and sensory hearing loss from retrospective datasets including gerbils, cross-sectional and longitudinal audiograms from older adults, a measure of speech recognition in noise, and histopathology case reports. Simulation results showed that well-approximated audiograms can produce accurate metabolic and sensory estimates. Estimates of metabolic and sensory components of age-related hearing loss differentiated gerbils with known strial and/or sensory pathologies based on age and exposures. For older adults, metabolic estimates consistently increased with age and were associated with poorer speech recognition in noise, while sensory estimates were related to sex and noise exposure differences. Histopathology case reports (with audiograms) that described strial and outer hair cell pathology in temporal bones from older donors showed significant differences in metabolic and sensory estimates, respectively. The results support the view that audiograms include information that can be used to estimate the metabolic and sensory components of age-related hearing loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.