ArticleClinical rheumatology2022
Varus-valgus knee laxity is related to a higher risk of knee osteoarthritis incidence and structural progression: data from the osteoarthritis initiative.
Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Radiographic Analysis of Lower Limb Alignment in Patients with Knee Osteoarthritis.Tomography (Ann Arbor, Mich.) · 2026Article
- Associations of medial collateral ligament and cartilage thickness with clinical outcomes in medial knee osteoarthritis: a cross-sectional study.Clinical rheumatology · 2026Article
- Changes in exercise adherence during use of an e-health application in individuals with knee osteoarthritis.Frontiers in rehabilitation sciences · 2026Article
- Self-reported physical activity and risk of primary knee replacement for osteoarthritis: a competing risks cohort analysis.BMC musculoskeletal disorders · 2025Article
- Age-specific comorbidity risks in osteoarthritis: implications for healthy aging across diverse populations.Archives of public health = Archives belges de sante publique · 2025Article
- Osteoarthritis.Nature reviews. Disease primers · 2025Review
- Addressing Biomechanical Errors in the Back Squat for Older Adults: A Clinical Perspective for Maintaining Neutral Spine and Knee Alignment.Journal of functional morphology and kinesiology · 2024Article
- A Radiographic Analysis of Coronal Morphological Parameters of Lower Limbs in Chinese Non-knee Osteoarthritis Populations.Orthopaedic surgery · 2024Article
- Risk factors associated with the occurrence of total knee arthroplasty in patients with knee osteoarthritis: a nested case-control study.Therapeutic advances in musculoskeletal disease · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNo prospective data have confirmed the effect of laxity on the development of KOA, and evidence of the relationship between laxity and KOA progression is still limited. This study aimed to reveal the risk of KOA incidence or progression in no laxity, mild laxity, and severe laxity knees.
methodsA total of 3610 knees without radiographic KOA in OAI (osteoarthritis initiative) database were prospectively divided into no, mild, and severe laxity groups to compare KOA incidence in 7-year follow-up via multi-variable Cox regression. Similarly, another 3155 knees with radiographic KOA were analyzed to investigate the effect of laxity on knee replacement surgery, joint space narrowing, malalignment, and pain.
resultsThe severe laxity group has a higher incidence of KOA (adjusted HR = 1.63, CI = [1.08, 2.47]). Laxity increased the risk of medial joint space narrowing (adjusted OR of mild laxity = 1.36, CI = [1.10, 1.68], adjusted OR of severe laxity = 1.51, CI = [1.06, 2.15]), malalignment (adjusted OR of mild laxity = 1.21, CI = [1.01, 1.45]; adjusted OR of severe laxity = 1.45, CI = [1.05, 2.00]), but had no significant effect on the risk of knee replacement (adjusted HR of mild laxity = 1.19, CI = [0.91, 1.54]; adjusted HR of severe laxity = 1.05, CI = [0.71, 1.54]) or pain (adjusted OR of mild laxity = 1.17, CI = [0.97, 1.42]; adjusted OR of severe laxity = 1.07, CI = [0.75, 1.51]).
conclusionCompared with no laxity, severe laxity predicts higher KOA incidence in subjects with risk factors. Either mild or severe laxity increases KOA structural progression. Varus-valgus laxity could become a potential predictor and therapeutic target of KOA. Key points • Severe knee laxity predicts higher KOA incidence. • Mild or severe knee laxity increases medial joint space narrowing and malalignment in KOA patients. • Intervention in varus-valgus laxity might be promising in the prevention and management of KOA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.