Evidence map›Paper›PMID 35064385›Full record

ArticleEuropean journal of applied physiology2022

Inhaled nitric oxide does not improve maximal oxygen consumption in endurance trained and untrained healthy individuals.

Andrew R Brotto, Devin B Phillips, Victoria L Meah, Bryan A Ross, Desi P Fuhr, Rhys I Beaudry, Sean van Diepen, Michael K Stickland

Abstract read
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In one paragraph

Article in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrew R BrottoFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Devin B PhillipsFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Victoria L MeahFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Bryan A RossDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3-135 Clinical Sciences Building 8440 112 St NW, Edmonton, AB, T6G 2B7, Canada.
Desi P FuhrDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3-135 Clinical Sciences Building 8440 112 St NW, Edmonton, AB, T6G 2B7, Canada.
Rhys I BeaudryDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3-135 Clinical Sciences Building 8440 112 St NW, Edmonton, AB, T6G 2B7, Canada.
Sean van DiepenDepartment of Critical Care and Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Michael K SticklandDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3-135 Clinical Sciences Building 8440 112 St NW, Edmonton, AB, T6G 2B7, Canada. michael.stickland@ualberta.ca.ORCID http://orcid.org/0000-0001-8234-4760
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious work suggests that endurance-trained athletes have superior pulmonary vasculature function as compared to untrained individuals, which may contribute to their greater maximal oxygen uptake ([Formula: see text]O

methodsSixteen endurance-trained and sixteen untrained individuals with normal lung function completed this randomized double-blind cross-over study over four sessions. Experimental cardiopulmonary exercise tests were completed while breathing either normoxia (placebo) or 40 ppm of iNO, on separate days (order randomized). On an additional day, echocardiography was used to determine pulmonary artery systolic pressure at rest and during sub-maximal exercise (60 Watts) while participants breathed normoxia or iNO.

resultsRight ventricular systolic pressure was significantly reduced by iNO during exercise (Placebo: 34 ± 7 vs. iNO: 32 ± 7; p = 0.04). [Formula: see text]O

conclusionDespite a reduction in right ventricular systolic pressure, the lack of change in [Formula: see text]O

Indexed as

Endurance TrainingAdministration, InhalationAdultEchocardiographyExercise TestFemaleHealthy VolunteersHumansMaleNitric OxideOxygen ConsumptionRespiratory Function TestsVascular ResistanceNitric OxideEndurance trained athletesExerciseInhaled nitric oxidePulmonary vasculatureRight ventricle

Identifiers

PMID35064385
OpenAlexW4207029363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.