Evidence map›Paper›PMID 35064299›Full record

ArticleInternational journal of colorectal disease2022

Impact of the viability assessment of lateral lymph node metastasis in rectal cancer after neoadjuvant chemoradiotherapy.

Kosuke Ozaki, Kazushige Kawai, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Hiroyuki Abe, Tetsuo Ushiku, Soichiro Ishihara

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kosuke OzakiDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. kou.ozaki0122@gmail.com.ORCID http://orcid.org/0000-0002-2775-2259
Kazushige KawaiDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Hiroaki NozawaDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Kazuhito SasakiDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Koji MuronoDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Shigenobu EmotoDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Hiroyuki AbeDepartment of Pathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Tetsuo UshikuDepartment of Pathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPTokyo Denki University · JP

Funding

Japan Agency for Medical Research and Development JP19cm0106502Japan Society for the Promotion of Science 19K09114Japan Society for the Promotion of Science 19K09115Japan Society for the Promotion of Science 20K21626Japan Society for the Promotion of Science London 18K07194
6 · The paper itself

Abstract

purposePreoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME) without lateral lymph node (LLN) dissection is widely performed for lower advanced rectal cancer. However, it is unclear whether residual cancer cells in the LLNs undergo apoptosis, disappear, or regrow if unresected.

methodsOverall, 293 consecutive patients with T3/4 rectal cancer who underwent CRT followed by radical surgery between September 2003 and December 2018 were retrospectively reviewed. We assessed apoptosis of the residual primary tumor, mesorectum lymph nodes (MLN), and LLN using M30 cytoDEATH immunostaining and evaluated the degree of apoptosis. The difference in the prognosis of the lateral lymph node metastasis positive (LLNM +) and lateral lymph node metastasis negative (LLNM-) groups was assessed.

resultsThere were 31 patients (10.6%) who were diagnosed with a complete response by hematoxylin and eosin (HE) staining. The residual cancer cells showed complete apoptosis in the primary lesion in 28 patients, in the metastatic MLN in only two patients, and in the metastatic LLN in one patient. The LLNM + group had a significantly poorer distant recurrence, recurrence-free survival, and overall survival than the LLNM- group.

conclusionThe majority of the residual cancer tissue in LNs observed by HE staining was found to be non-apoptotic. If LLN metastasis is suspected on pretreatment imaging, performing LLN dissection together with TME should be considered.

Indexed as

Neoadjuvant TherapyRectal NeoplasmsChemoradiotherapyHumansLymphatic MetastasisLymph Node ExcisionLymph NodesNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesChemoradiotherapyLateral lymph node metastasisRectal cancer

Identifiers

PMID35064299
OpenAlexW4207018665

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.