ArticleArchives of orthopaedic and trauma surgery2023
Long-term cost-effectiveness of matrix-associated chondrocyte implantation in the German health care system: a discrete event simulation.
Article in Archives of orthopaedic and trauma surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Minimum 10-Year Outcomes of Matrix-Induced Autologous Chondrocyte Implantation in the Knee: A Systematic Review.The American journal of sports medicine · 2024Pooled it
- Pooled it
- Clinical follow-up 7-12 years after autologous chondrocyte implantation with a hydrogel scaffold (CaReS©) in knee cartilage defects.Wiener klinische Wochenschrift · 2026Article
- Application and benefit analysis of needle arthroscopy for joint disease diagnosis and treatment.iScience · 2026Review
- Management of Isolated Tibial Plateau Defect in the Setting of Anterior Cruciate Ligament Reconstruction and Meniscus Repair: A Case Report and Review of the Literature.Case reports in orthopedics · 2025Article
- Infiltration therapy in the context of cartilage surgery.Archives of orthopaedic and trauma surgery · 2024Review
- Treatment of cartilage defects in the patellofemoral joint with matrix-associated autologous chondrocyte implantation effectively improves pain, function, and radiological outcomes after 5-7 years.Archives of orthopaedic and trauma surgery · 2024Article
- Cartilage Biopsy for Autologous Cell-Based Repair of the Knee in the Wide-Awake Setting Using Needle Arthroscopy.Arthroscopy techniques · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCartilage defects in the knee can be caused by injury, various types of arthritis, or degeneration. As a long-term consequence of cartilage defects, osteoarthritis can develop over time, often leading to the need for a total knee replacement (TKR). The treatment alternatives of chondral defects include, among others, microfracture, and matrix-associated autologous chondrocyte implantation (M-ACI). The purpose of this study was to determine cost-effectiveness of M-ACI in Germany with available mid- and long-term outcome data, with special focus on the avoidance of TKR. MATERIALS AND
methodsWe developed a discrete-event simulation (DES) that follows up individuals with cartilage defects of the knee over their lifetimes. The DES was conducted with a status-quo scenario in which M-ACI is available and a comparison scenario with no M-ACI available. The model included 10,000 patients with articular cartilage defects. We assumed Weibull distributions for short- and long-term effects for implant failures. Model outcomes were costs, number of TKRs, and quality-adjusted life years (QALYs). All analyses were performed from the perspective of the German statutory health insurance.
resultsThe majority of patients was under 45 years old, with defect sizes between 2 and 7 cm
conclusionM-ACI is projected to be a highly cost-effective treatment for chondral defects of the knee in the German healthcare setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.