ArticleNPJ Parkinson's disease2022
Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson's disease.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03213873 (Effects of the HiBalance-program), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of the HiBalance-program: Linking Clinical Signs and Symptoms to Changes in the Brain in People With Parkinson´s Disease
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Current interventional model for movement in Parkinson's disease: network meta-analysis based on the improvement of motor ability.Frontiers in aging neuroscience · 2024Pooled it
- Changes of brain-derived neurotrophic factor (BDNF) levels after different exercise protocols: a systematic review of clinical studies in Parkinson's disease.Frontiers in physiology · 2024Pooled it
- Parkinson's disease motor intervention patterns: a network meta-analysis based on patient motor function.Frontiers in neurology · 2024Pooled it
- Effects of HiBalance training program on physical function of individuals with idiopathic Parkinson disease: a systematic review and meta-analysis.European geriatric medicine · 2023Pooled it
- Does Exercise Attenuate Disease Progression in People With Parkinson's Disease? A Systematic Review With Meta-Analyses.Neurorehabilitation and neural repair · 2023Pooled it
- Baseline predictors of response to a group-based speech and communication intervention in Parkinson's disease: A secondary analysis of a randomized controlled trial.Journal of Parkinson's disease · 2026Trial
- Home physical therapy versus telerehabilitation in improving motor function and quality of life in Parkinson's disease: a randomized controlled trial.BMC geriatrics · 2024Trial
- Exploring Responsiveness to Highly Challenging Balance and Gait Training in Parkinson's Disease.Movement disorders clinical practice · 2024Trial
- Dual-Task Exercises for Dynamic Balance, Motor Function, Functional Mobility, and Dual-Tasking in Individuals With Parkinson's Disease: A Meta-Analysis With Meta-Regression.Annals of rehabilitation medicine · 2026Article
- Sedentary behavior modifies the effect of balance rehabilitation on balance discordance in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Physiotherapy interventions for balance impairments in Parkinson's disease: evidence from a systematic review and dose-response meta-analysis.NPJ Parkinson's disease · 2026Article
- A Preliminary Mechanics-Informed Machine Learning Framework for Objective Assessment of Parkinson's Disease and Rehabilitation Outcomes.Diagnostics (Basel, Switzerland) · 2025Article
- Functional remapping in networks of the Parkinsonian brain: A preclinical neuroimaging perspective with clinical correlates.Translational neuroscience · 2025Review
- Effects of a treadmill and oculomotor dual-task intervention vs. -nordic walking on balance in Parkinson's disease patients - a pilot study.Clinical parkinsonism & related disorders · 2025Article
- Investigating underlying brain structures and influence of mild and subjective cognitive impairment on dual-task performance in people with Parkinson's disease.Scientific reports · 2024Article
- Effects and Mechanisms of Exercise on Brain-Derived Neurotrophic Factor (BDNF) Levels and Clinical Outcomes in People with Parkinson's Disease: A Systematic Review and Meta-Analysis.Brain sciences · 2024Review
- Dose-response effects of physical exercise standardized volume on peripheral biomarkers, clinical response, and brain connectivity in Parkinson's disease: a prospective, observational, cohort study.Frontiers in neurology · 2024Article
- Speech and neuroimaging effects following HiCommunication: a randomized controlled group intervention trial in Parkinson's disease.Brain communications · 2024Article
- Implicit Motor Sequence Learning in People with Mild to Moderate Parkinson's Disease: Behavior and Related Brain Function.Journal of Parkinson's disease · 2023Article
- Exercise modulation of BDNF/TrkB signaling in Parkinson's disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
Balance dysfunction is a disabling symptom in people with Parkinson's disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cognitive symptoms, and alter task-evoked brain activity in people with PD. We performed a double-blind randomised controlled trial (RCT) where 95 participants with PD were randomised to either HiBalance (n = 48) or a control group (n = 47). We found no significant group by time effect on balance performance (b = 0.4 95% CI [-1, 1.9], p = 0.57) or on our secondary outcomes, including the measures of task-evoked brain activity. The findings of this well-powered, double-blind RCT contrast previous studies of the HiBalance programme but are congruent with other double-blind RCTs of physical exercise in PD. The divergent results raise important questions on how to optimise physical exercise interventions for people with PD.Preregistration clinicaltrials.gov: NCT03213873.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.