Evidence map›Paper›PMID 35064092›Full record

ArticleRMD open2022

What amount of structural damage defines sacroiliitis: a CT study.

Kay Geert A Hermann, Katharina Ziegeler, Virginie Kreutzinger, Denis Poddubnyy, Fabian Proft, Dominik Deppe, Juliane Greese, Joachim Sieper, Torsten Diekhoff

Open access · goldAbstract read
In one paragraph

Article in RMD open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Axial Imaging in Spondyloarthritis.Rheumatic diseases clinics of North America · 2024
    Review
  4. Imaging in psoriatic arthritis: established methods and emerging techniques.Therapeutic advances in musculoskeletal disease · 2024
    Review
  5. Review
  6. Observational
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kay Geert A Hermann *Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany kgh@charite.de.ORCID 0000-0001-6142-3814
Katharina Ziegeler *Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-9763-2420
Virginie KreutzingerVivantes Klinikum im Friedrichshain, Berlin, Germany.
Denis PoddubnyyDivision of Gastroenterology, Infectious Diseases and Rheumatology, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-4537-6015
Fabian ProftDivision of Gastroenterology, Infectious Diseases and Rheumatology, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-4306-033X
Dominik DeppeDepartment of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Juliane GreeseDepartment of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Joachim SieperDivision of Gastroenterology, Infectious Diseases and Rheumatology, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-0285-9890
Torsten DiekhoffDepartment of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-3593-1449
Charité - Universitätsmedizin Berlin · DEKlinikum im Friedrichshain · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo propose a data-driven definition for structural changes of sacroiliac (SI) joints in the context of axial spondyloarthritis (axSpA) imaging on a large collective of CT datasets.

methods546 individuals (102 axSpA, 80 non-axSpA low back pain and 364 controls without back pain) with SI joint CTs were evaluated for erosions, sclerosis and ankylosis using a structured scoring system. Lesion frequencies and spatial distribution were compared between groups. Diagnostic performance (sensitivity (SE), specificity (SP), positive predictive values, negative predictive values and positive and negative likelihood ratios) was calculated for different combinations of imaging findings. Clinical diagnosis served as standard of reference.

resultsAnkylosis and/or erosions of the middle and dorsal joint portions yielded the best diagnostic performance with SE 67.6% and SP 96.3%. Inclusion of ventral erosions and sclerosis resulted in lower diagnostic performance with SE 71.2%/SP 92.5% and SE 70.6%/SP 90.0%, respectively.

conclusionsSclerosis and ventrally located erosions of SI joints have lower specificity on CT of the SI joint in the context of axSpA imaging. Ankylosis and/or erosions of the middle and dorsal joint portions show a strong diagnostic performance and are appropriate markers of a positive SI joint by CT.

Indexed as

SacroiliitisSpondylarthritisHumansMagnetic Resonance ImagingSacroiliac JointTomography, X-Ray Computedankylosing spondylitisankylosiserosionlow back painsclerosis

Identifiers

PMID35064092
PMCPMC8785200
OpenAlexW4207024989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.