ArticleThorax2022
Neural ventilatory drive decline as a predominant mechanism of obstructive sleep apnoea events.
Article in Thorax, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Acetazolamide to prevent ventilatory drive withdrawal in REM sleep apnoea: a randomised controlled trial.Thorax · 2026Trial
- Trial
- Gefapixant as a P2X3 receptor antagonist treatment for obstructive sleep apnea: a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Trial
- Effect of Pimavanserin on the Respiratory Arousal Threshold from Sleep: A Randomized Trial.Annals of the American Thoracic Society · 2022Trial
- Phrenic nerve stimulation enhances upper airway patency during drug-induced sleep endoscopy in obstructive sleep apnea.Annals of the American Thoracic Society · 2026Article
- Mechanisms of upper airway muscle control in sleep reveal therapeutic targets for obstructive sleep apnea.American journal of respiratory cell and molecular biology · 2026Review
- Association Between Obstructive Sleep Apnea and Preoperative Cardiopulmonary Fitness in Patients Undergoing Sleeve Gastrectomy: A Real-World Study.Obesity surgery · 2026Article
- Unraveling sleep apnea dynamics: quantifying loop gain using dynamical modeling of ventilatory control.Sleep · 2026Article
- Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research.British journal of clinical pharmacology · 2026Review
- The Where and the Why of Obstructive Sleep Apnea.Annals of the American Thoracic Society · 2025Article
- Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Pulmonary Function and Nocturnal Hypoxemia Patterns in Patients with Obstructive Sleep Apnea.Journal of clinical medicine · 2025Article
- Compartmental inspiratory genioglossus electromyographic activity in supine, awake individuals with and without obstructive sleep apnoea.The Journal of physiology · 2025Article
- Phenotyping Using Polysomnography Attributes Reduced Respiratory Events after Continuous Positive Airway Pressure Therapy to Improved Upper Airway Collapsibility.Annals of the American Thoracic Society · 2025Article
- Article
- Morphological Prediction of Continuous Positive Airway Pressure-associated Acute Respiratory Instability.Annals of the American Thoracic Society · 2025Article
- Altered control of breathing in a rat model of allergic lower airway inflammation.Journal of neurophysiology · 2024Article
- Association between overnight repetitive respiratory events and the accumulation of genioglossus fatigue in male patients with severe obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review.Journal of clinical medicine · 2024Review
- Physiological Determinants of Snore Loudness.Annals of the American Thoracic Society · 2024Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn the classic model of obstructive sleep apnoea (OSA), respiratory events occur with sleep-related dilator muscle hypotonia, precipitating increased neural ventilatory 'drive'. By contrast, a drive-dependent model has been proposed, whereby
methodsIn 50 OSA patients (5-91 events/hour), we recorded ventilation ('flow', oronasal mask and pneumotach) and ventilatory drive (calibrated intraoesophageal diaphragm electromyography, EMG) overnight. Flow and drive during events were ensemble averaged; patients were classified as
resultsOn average, ventilatory drive fell (rather than rose) during events (-20 (-42 to 3)%
conclusionsIn contrast to the prevailing view, patients with OSA predominantly exhibit
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.