ArticleNeuroImage. Clinical2022
Associations between neonatal hypoglycaemia and brain volumes, cortical thickness and white matter microstructure in mid-childhood: An MRI study.
Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Oral dextrose gel to prevent hypoglycaemia in at-risk neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Knowledge, attitudes, and practices in pediatric hypoglycemia in Italy (KAPPHy study).Journal of endocrinological investigation · 2026Article
- Neonatal hypoglycemia and neurodevelopment outcomes among late preterm infants: a prospective cohort study.Pediatric research · 2026Article
- Microstructural white matter changes in infants with transient neonatal hypoglycemia revealed by diffusion tensor imaging: a preliminary cross-sectional study.Quantitative imaging in medicine and surgery · 2026Article
- Early postnatal risk stratification for severe adverse outcomes in twin neonates admitted to the neonatal intensive care unit: development and temporal validation of an interpretable machine learning model.Translational pediatrics · 2026Article
- Practice Variations in Pediatric Hypoglycemia Management: A Survey of Emergency Medicine Physicians.Cureus · 2025Article
- [Expert consensus on the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal hypoglycemia (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Incidence and risk factors of neonatal hypoglycemia at Hawassa University Comprehensive Specialized Hospital.PloS one · 2025Article
- Neonatal Hypoglycemia and Neurodevelopmental Outcomes-An Updated Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2024Review
- Prophylactic dextrose gel use in newborns at risk for hypoglycemia.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Neonatal Hypoglycemia and Neurocognitive Function at School Age: A Prospective Cohort Study.The Journal of pediatrics · 2024Article
- Diabetes mellitus in older persons with neurocognitive disorder: overtreatment prevalence and associated structural brain MRI findings.BMC geriatrics · 2024Article
- Subcortical brain volumes in neonatal hypoxic-ischemic encephalopathy.Pediatric research · 2023Article
- Size at birth predicts later brain volumes.Scientific reports · 2023Article
- Neurodevelopmental correlates of caudate volume in children born at risk of neonatal hypoglycaemia.Pediatric research · 2023Article
- Neonatal hypoglycemia: lack of evidence for a safe management.Frontiers in endocrinology · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal hypoglycaemia is a common metabolic disorder that may cause brain damage, most visible in parieto-occipital regions on MRI in the acute phase. However, the long term effects of neonatal hypoglycaemia on the brain are not well understood. We investigated the association between neonatal hypoglycaemia and brain volumes, cortical thickness and white matter microstructure at 9-10 years. Children born at risk of neonatal hypoglycaemia at ≥ 36 weeks' gestation who took part in a prospective cohort study underwent brain MRI at 9-10 years. Neonatal hypoglycaemia was defined as at least one hypoglycaemic episode (at least one consecutive blood glucose concentration < 2.6 mmol/L) or interstitial episode (at least 10 min of interstitial glucose concentrations < 2.6 mmol/L). Brain volumes and cortical thickness were computed using Freesurfer. White matter microstructure was assessed using tract-based spatial statistics. Children who had (n = 75) and had not (n = 26) experienced neonatal hypoglycaemia had similar combined parietal and occipital lobe volumes and no differences in white matter microstructure at nine years of age. However, those who had experienced neonatal hypoglycaemia had smaller caudate volumes (mean difference: -557 mm
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