Evidence map›Paper›PMID 35063745›Full record

ArticleDiabetes & metabolic syndrome2022

Hypermethylation of miRNA-17-92 cluster in peripheral blood mononuclear cells in diabetic retinopathy.

Qianyi Luo, Surya Sruthi Bhamidipalli, George J Eckert, Ashay D Bhatwadekar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & metabolic syndrome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Transcriptomic Profile of LinBMC genomics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Qianyi LuoDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute. Indiana University, Indianapolis, IN, 46202, USA.
Surya Sruthi BhamidipalliDepartment of Biostatistics & Health Data Science, Indiana University, Indianapolis, IN, 46202, USA.
George J EckertDepartment of Biostatistics & Health Data Science, Indiana University, Indianapolis, IN, 46202, USA.
Ashay D BhatwadekarDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute. Indiana University, Indianapolis, IN, 46202, USA. Electronic address: abhatwad@iupui.edu.
Indiana University – Purdue University Indianapolis · USHypertension Institute · USMidwest Eye Institute · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
miR-92a as a biomarker of diabetic retinopathyR01EY032080 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BHATWADEKAR, ASHAY D · 2021 to 2025
$2.6M
Retinal dysfunction in Alzheimer's disease mouse modelsR01EY027779 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BHATWADEKAR, ASHAY D · 2017 to 2021
$2.4M
NCATS NIH HHS UL1 TR002529NEI NIH HHS R01 EY027779NEI NIH HHS R01 EY032080
6 · The paper itself

Abstract

BACKGROUND AND

aimsDiabetic retinopathy (DR) is the most common complication of diabetes. The inflammatory milieu of diabetes results in changes throughout the body. This study asked whether epigenetic changes in peripheral blood mononuclear cells (PBMCs) reflect DR severity.

methodsPBMCs were separated from the whole blood of DR individuals using density gradient centrifugation. DNA was isolated, and methylation of micro-RNA (miR)-17-92 cluster was evaluated.

resultsWe observed that the miR-17-92 cluster was hypermethylated in DR individuals; specifically, this change was most remarkable with proliferative-DR (PDR).

conclusionsmiR-17-92 methylation in PBMCs could help understand DR's pathogenesis and identify individuals at the risk of severe DR for early intervention.

Indexed as

Diabetes MellitusDiabetic RetinopathyMicroRNAsRNA, Long NoncodingHumansLeukocytes, MononuclearMicroRNAsMIR17HG, humanRNA, Long NoncodingDiabetic retinopathyEpigenetic regulationmiRNA

Identifiers

PMID35063745
PMCPMC8920756
OpenAlexW4205351201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.