Evidence map›Paper›PMID 35063702›Full record

ArticleInfectious diseases now2022

Evolution of anti-SARS-CoV-2 immune response in a cohort of French healthcare workers followed for 7 months.

B Pilmis, I Elkaibi, G Péan de Ponfilly, H Daikha, A Bouzid, A Guihot, N Castreau, P Pradere, H Ketatni, A Mondragon and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Infectious diseases now, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04488484 (Medical and Serological Follow-up of the Staff of the Paris Saint-Joseph Hospital Group), which is not on this map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04488484 nacompletednot on this map

Medical and Serological Follow-up of the Staff of the Paris Saint-Joseph Hospital Group

TypeinterventionalSponsorFondation Hôpital Saint-JosephRan2020 to 2022Enrolled80ConditionsCOVID-19ArmsSerology test follow-up
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Prevalence and symptoms of Long Covid-19 in the workplace.Occupational medicine (Oxford, England) · 2025
    Pooled it
  2. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Pooled it
  3. Pooled it
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  8. SARS-CoV-2 antibodies persist up to 12 months after natural infection in healthy employees working in non-medical contact-intensive professions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

B PilmisÉquipe mobile de microbiologie clinique, Groupe hospitalier Paris Saint-Joseph, Paris, France; Institut Micalis UMR 1319, université Paris-Saclay, INRAe, AgroParisTech, Châtenay, Malabry, France. Electronic address: bpilmis@ghpsj.fr.
I ElkaibiLaboratoire de biologie médicale, Groupe hospitalier Saint-Joseph, Paris, France.
G Péan de PonfillyInstitut Micalis UMR 1319, université Paris-Saclay, INRAe, AgroParisTech, Châtenay, Malabry, France; Service de microbiologie clinique, Groupe hospitalier Paris Saint-Joseph, Paris, France.
H DaikhaLaboratoire de biologie médicale, Groupe hospitalier Saint-Joseph, Paris, France.
A BouzidDépartement d'immunologie, Assistance Publique-Hôpitaux de Paris (AP-HP), hôpital Pitié-Salpêtrière, 75013 Paris, France.
A GuihotDépartement d'immunologie, Assistance Publique-Hôpitaux de Paris (AP-HP), hôpital Pitié-Salpêtrière, 75013 Paris, France; Centre d'immunologie et des maladies infectieuses (CIMI-Paris), Sorbonne université (University Paris 06), Inserm U1135, hôpital Pitié-Salpêtrière, Paris, France.
N CastreauService de santé au travail, Groupe hospitalier Paris Saint-Joseph, Paris, France.
P PradereService de pneumologie et transplantation pulmonaire, Groupe hospitalier Paris Saint-Joseph, Paris, France.
H KetatniLaboratoire de biologie médicale, Groupe hospitalier Saint-Joseph, Paris, France.
A MondragonService de santé au travail, Groupe hospitalier Paris Saint-Joseph, Paris, France; Service de rhumatologie, Groupe hospitalier Paris Saint-Joseph, Paris, France.
G HayemService de rhumatologie, Groupe hospitalier Paris Saint-Joseph, Paris, France.
J Le PavecService de pneumologie et transplantation pulmonaire, Groupe hospitalier Paris Saint-Joseph, Paris, France.
S LaplancheLaboratoire de biologie médicale, Groupe hospitalier Saint-Joseph, Paris, France.
A Le MonnierInstitut Micalis UMR 1319, université Paris-Saclay, INRAe, AgroParisTech, Châtenay, Malabry, France; Service de microbiologie clinique, Groupe hospitalier Paris Saint-Joseph, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to understand the immune response among healthcare workers (HCWs) following SARS-CoV-2 infection, and to determine the infection prevalence during the first wave of the pandemic among workers in our hospital.

methodsDetermination of the serological status against SARS-CoV-2 (nucleocapsid) was offered to all HCWs. All HCWs with positive SARS-CoV-2 serology were proposed to be included in a longitudinal medical and serological follow-up (anti-spike) for 7months.

resultsWe included 3062 HCWs; 256 (8.4%) were positive for anti-SARS-CoV-2 nucleocapsid IgG. Among them, early decrease in the anti-nucleocapsid antibody index was observed between the first (S1) and second (S2) serology samplings in 208 HCWs (84.2%). The initial anti-nucleocapsid IgG index seemed to be related to the HCWs' age. Seventy-four HCWs were included in the 7-month cohort study. Among them, 69 (90.5%) had detectable anti-spike IgG after 7months and 24 (32.4%) reported persistent symptoms consistent with post-acute COVID-19 syndrome diagnosis.

conclusionThe prevalence of serological positivity among HCWs was 6.7%. Infection should be followed by vaccination because of antibody decrease.

Indexed as

COVID-19Health PersonnelAntibodies, ViralCohort StudiesFranceHumansImmunityPost-Acute COVID-19 SyndromeSARS-CoV-2Antibodies, ViralAnti-spike IgGCOVID-19Healthcare workersSARS-CoV-2Vaccination

Identifiers

PMID35063702
PMCPMC8767912

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.