Evidence map›Paper›PMID 35063424›Full record

ArticlePhysiology & behavior2022

Time to drink: Activating lateral hypothalamic area neurotensin neurons promotes intake of fluid over food in a time-dependent manner.

Gizem Kurt, Nandan Kodur, Cristina Rivera Quiles, Chelsea Reynolds, Andrew Eagle, Tom Mayer, Juliette Brown, Anna Makela, Raluca Bugescu, Harim Delgado Seo and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Physiology & behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Fluid transitions.Neuropharmacology · 2024
    Review
  7. Article
  8. Article
  9. The cognitive (lateral) hypothalamus.Trends in cognitive sciences · 2024
    Review
  10. Article
  11. Obesity in male volcano miceFrontiers in nutrition · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Gizem KurtDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Nandan KodurDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Cristina Rivera QuilesDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Chelsea ReynoldsDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Andrew EagleDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Tom MayerDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Juliette BrownDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.
Anna MakelaDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Raluca BugescuDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Harim Delgado SeoDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Quinn E CarrollDepartment of Psychology and the Center for Ingestive Behavior Research, University at Buffalo, the State University of New York, Buffalo, NY 14226, USA.
Derek DanielsDepartment of Psychology and the Center for Ingestive Behavior Research, University at Buffalo, the State University of New York, Buffalo, NY 14226, USA.
A J RobisonDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Michelle Mazei-RobisonDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Gina LeinningerDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: leinning@msu.edu.
Michigan State University · USUniversity at Buffalo, State University of New York · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Role of Lateral Hypothalamic Neurotensin Neurons in Energy BalanceR01DK103808 · NIDDK · MICHIGAN STATE UNIVERSITY · PI Gina Marie Leinninger · 2014 to 2026
$4.8M
Bridge to the PhD in NeuroscienceR25NS090989 · NINDS · MICHIGAN STATE UNIVERSITY · PI IRVING E VEGA · 2015 to 2026
$4.0M
GLP-1 Effects in Water and Salt IntakeR01DK107500 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DANIELS, DEREK · 2016 to 2019
$1.7M
Role of VTA Neurotensin Receptor-1 Expressing Neurons in Energy BalanceF31DK121373 · NIDDK · MICHIGAN STATE UNIVERSITY · PI PEREZ-BONILLA, PATRICIA · 2019 to 2021
$99k
NIDDK NIH HHS F31 DK121373NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK103808NIDDK NIH HHS R01 DK107500NINDS NIH HHS R25 NS090989
6 · The paper itself

Abstract

The lateral hypothalamic area (LHA) is essential for ingestive behavior but has primarily been studied in modulating feeding, with comparatively scant attention on drinking. This is partly because most LHA neurons simultaneously promote feeding and drinking, suggesting that ingestive behaviors track together. A notable exception are LHA neurons expressing neurotensin (LHA

Indexed as

Hypothalamic Area, LateralNeurotensinFoodNeuronsWaterNeurotensinWateraCSF, Artificial cerebrospinal fluidARC, Arcuate nucleusbody weightCEA, Central amygdalaCNO, Clozapine N-OxideCPP, Conditioned place preferenceDR, Dorsal rapheDREADDDREADD, Designer receptor exclusively activated by designer drugsfeedingFR-1, Fixed ratio-1homeostasislateral preoptic area (LPO)LepRb, Long form of the leptin receptorLHALHA, Lateral hypothalamic areaLHA(Nts), Lateral hypothalamic area neuotensin-expressinglHb, Lateral habenulaLPO, Lateral preoptic areaLT, Lateral terminalisMnPO, Median preoptic areaModRabies, Genetically modified rabies virus, EnvA-∆G-Rabies-mCherryneurotensin receptorNts, NeurotensinNTS, Nucleus of solitary tractNtsR1, Neurotensin receptor-1NtsR2, Neurotensin receptor-2OVLT, Organum vasculosum lamina terminalisPAG, Periaqueductal grayPB, Parabrachial areaPR, Progressive ratioPVH, Paraventricular nucleus of hypothalamusrewardSFO, Subfornical organSNc, Substantia nigra compactaSO, Supraoptic nucleusTVA, avian viral receptor proteinVEH, VehicleVTA, Ventral tegmental areaWaterWT, Wild type

Identifiers

PMID35063424
PMCPMC8844224
OpenAlexW4205617277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.