Evidence map›Paper›PMID 35063288›Full record

ArticleDiabetes research and clinical practice2022

Higher rates of all-cause mortality and resource utilization during episodes-of-care for diabetic foot ulceration.

Brian J Petersen, Walter T Linde-Zwirble, Tze-Woei Tan, Gary M Rothenberg, Simon J Salgado, Jonathan D Bloom, David G Armstrong

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes research and clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07291817 (Intermittent Negative Pressure for Patients With Diabetic Foot Ulcers), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07291817 narecruitingnot on this mapstarted 2025, after this paper: background citation

Intermittent Negative Pressure for Patients With Diabetic Foot Ulcers (INPRESS) Study

TypeinterventionalSponsorLo Zhiwen JosephRan2025 to 2026Enrolled30ConditionsDiabetic Foot UlcerArmsFlowOx
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Brian J PetersenPodimetrics, Inc., 100 Dover St, Somerville, MA 02144, USA. Electronic address: authors@podiography.org.
Walter T Linde-ZwirbleTrexin Consulting, Inc., 601 Carlson Parkway, Minneapolis, MN 55305, USA. Electronic address: wtlz@me.com.
Tze-Woei TanUniversity of Arizona College of Medicine, Department of Surgery, Tucson, AZ 85724, USA. Electronic address: ttan@arizona.edu.
Gary M RothenbergUniversity of Michigan Medical School, Department of Internal Medicine, Ann Arbor, MI 48109, USA.
Simon J SalgadoPodimetrics, Inc., 100 Dover St, Somerville, MA 02144, USA.
Jonathan D BloomPodimetrics, Inc., 100 Dover St, Somerville, MA 02144, USA.
David G ArmstrongKeck School of Medicine of University of Southern California, Department of Surgery, Los Angeles, CA, USA.
Sensimetrics Corporation · USUniversity of Arizona · USUniversity of Michigan–Ann Arbor · USUniversity of Southern California · US

Funding

Determinants in Limb Preservation in Hispanics and Native AmericansK23DK122126 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAN, TZE-WOEI · 2019 to 2023
$845k
NIDDK NIH HHS K23 DK122126
6 · The paper itself

Abstract

aimsOur primary objective was to determine whether all-cause rates of mortality and resource utilization were higher during periods of diabetic foot ulceration. In support of this objective, a secondary objective was to develop and validate an episode-of-care model for diabetic foot ulceration.

methodsWe evaluated data from the Medicare Limited Data Set between 2013 and 2019. We defined episodes-of-care by clustering diabetic foot ulcer related claims such that the longest time interval between consecutive claims in any cluster did not exceed a duration which was adjusted to match two aspects of foot ulcer episodes that are well-established in the literature: healing rate at 12 weeks, and reulceration rate following healing. We compared rates of outcomes during periods of ulceration to rates immediately following healing to estimate incidence ratios.

resultsThe episode-of-care model had a minimum mean relative error of 4.2% in the two validation criteria using a clustering duration of seven weeks. Compared to periods after healing, all-cause inpatient admissions were 2.8 times more likely during foot ulcer episodes and death was 1.5 times more likely.

conclusionsA newly-validated episode-of-care model for diabetic foot ulcers suggests an underappreciated association between foot ulcer episodes and all-cause resource utilization and mortality.

Indexed as

Diabetes MellitusDiabetic FootAgedHospitalizationHumansInpatientsMedicareUnited StatesWound HealingAmputationsDiabetic foot ulcersEpisodes of careHospitalizationsPreventionResource utilization

Identifiers

PMID35063288
PMCPMC8932197
OpenAlexW4206513718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.