Trial reportBiological psychiatry2022
Deep Brain Stimulation for Depression Informed by Intracranial Recordings.
Trial report in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 153 citations in OpenAlex.
- Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation.Journal of neural engineering · 2026Trial
- Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Trial
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- Stimulation-evoked orbitofrontal activity as a biomarker for DBS personalization in depression.medRxiv : the preprint server for health sciences · 2026Article
- Preliminary clinical and electrophysiological findings of NAc/ALIC deep brain stimulation strategy for treatment-resistant depression.iScience · 2026Article
- A week in the life of the human brain reveals stable states punctuated by chaotic-like transitions.Nature communications · 2026Article
- Conserved fiber topography of the anterior limb of the internal capsule in treatment-resistant psychiatric patients.bioRxiv : the preprint server for biology · 2026Article
- Toward Individualized Deep Brain Stimulation: A Stereoelectroencephalography-Based Workflow for Neurostimulation Target Identification.Neuromodulation : journal of the International Neuromodulation Society · 2026Article
- Review
- Association of low-frequency oscillations with target selection between the subthalamic nucleus and globus pallidus internus in blepharospasm-oromandibular dystonia.Journal of neurology · 2026Article
- A clinical study on the augmented therapeutic effects of transcutaneous auricular vagus nerve stimulation combined with repetitive transcranial magnetic stimulation in the treatment of moderate-to-severe depression.Pakistan journal of medical sciences · 2026Article
- Pathway to Adaptive Neuromodulation: Modeling Epileptogenic Brain States Using SEEG.Epilepsy currents · 2026Article
- Combinatorial effects of multi-site stimulation on depression-related brain regions: clinical data analysis and predictive modeling.Frontiers in psychiatry · 2026Article
- Deep brain stimulation clinical trials: a framework to accelerate recruitment, retention, and technology translation.Frontiers in human neuroscience · 2026Article
- Cerebellar deep brain stimulation rescues Purkinje cell mitochondrial density in a genetic mouse model of cerebellar ataxia.Brain research bulletin · 2026Article
- Recalibrating the mind: The connectomic and ethical renaissance of laser-guided precision psychosurgery for refractory affective illness.Surgical neurology international · 2026Article
- Psychometric Properties of a Novel Affective Bias Task and Its Application in Clinical and Nonclinical Populations.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Real-time Bayesian optimization of deep brain stimulation for personalized cognitive control enhancement.bioRxiv : the preprint server for biology · 2025Article
- Towards individualized deep brain stimulation: A stereoelectroencephalography-based workflow for neurostimulation target identification.bioRxiv : the preprint server for biology · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 1 country.
Funding
Abstract
The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.