Evidence map›Paper›PMID 35063085›Full record

ArticleCell2022

Cellular architecture of human brain metastases.

Hugo Gonzalez, Wenbin Mei, Isabella Robles, Catharina Hagerling, Breanna M Allen, Trine Line Hauge Okholm, Ankitha Nanjaraj, Tamara Verbeek, Sandhya Kalavacherla, Merel van Gogh and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 192 citations in OpenAlex.

  1. Review
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  10. Tumor-Associated Macrophages Promote Brain Metastasis.bioRxiv : the preprint server for biology · 2026
    Article
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  14. Review
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Hugo GonzalezDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA. Electronic address: hugo.gonzalezvelozo@ucsf.edu.
Wenbin MeiDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.
Isabella RoblesDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.
Catharina HagerlingDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA; Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, SE 221 85 Lund, Sweden.
Breanna M AllenGraduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA, USA; Departments of Otolaryngology-Head and Neck Surgery and Microbiology & Immunology, Parker Institute for Cancer Immunotherapy, Chan Zuckerberg Biohub, University of California, San Francisco, San Francisco, CA, USA.
Trine Line Hauge OkholmDepartments of Otolaryngology-Head and Neck Surgery and Microbiology & Immunology, Parker Institute for Cancer Immunotherapy, Chan Zuckerberg Biohub, University of California, San Francisco, San Francisco, CA, USA.
Ankitha NanjarajDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.
Tamara VerbeekDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.
Sandhya KalavacherlaDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.
Merel van GoghDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.
Stephen GeorgiouDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.
Mariza DarasDepartment of Neurological Surgery, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA.
Joanna J PhillipsHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA.
Matthew H SpitzerGraduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA, USA; Departments of Otolaryngology-Head and Neck Surgery and Microbiology & Immunology, Parker Institute for Cancer Immunotherapy, Chan Zuckerberg Biohub, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.
Jeroen P RooseDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA. Electronic address: jeroen.roose@ucsf.edu.
Zena WerbDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.
University of California, San Francisco · USParker Institute for Cancer Immunotherapy · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHN KURIYAN · 2011 to 2026
$31.1M
Role of Metalloproteinases in Mammary Gland RemodelingR01CA057621 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 1993 to 2017
$9.0M
Balanced signaling cues to guide cell transitions in the blood lineage continuumR01HL120724 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAKRABORTY, ARUP K., NOLAN, GARRY P · 2015 to 2019
$3.7M
Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependenceR01CA187318 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEROEN ROOSE · 2015 to 2026
$3.6M
Integrative approach to heterogeneity in breast cancer metastasisU01CA199315 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI, SPELLMAN, PAUL T. · 2016 to 2020
$3.2M
Role of GATA3 in transcriptional pathways suppressing breast cancer metastasisR01CA190851 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 2015 to 2019
$2.0M
Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling VariantsR01AI104789 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROOSE, JEROEN · 2014 to 2018
$1.9M
Quantitatively modeling immune responses to cancerDP5OD023056 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPITZER, MATTHEW · 2016 to 2020
$1.9M
(PQC4) Fate of cells disseminating from human breast cancer xenograftsR01CA180039 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 2013 to 2016
$1.3M
Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling VariantsR56AI104789 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROOSE, JEROEN · 2021 to 2021
$242k
NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA057621NCI NIH HHS R01 CA180039NCI NIH HHS R01 CA187318NCI NIH HHS R01 CA190851NCI NIH HHS U01 CA199315NHLBI NIH HHS R01 HL120724NIAID NIH HHS P01 AI091580NIAID NIH HHS R01 AI104789NIAID NIH HHS R56 AI104789NIH HHS DP5 OD023056
6 · The paper itself

Abstract

Brain metastasis (BrM) is the most common form of brain cancer, characterized by neurologic disability and an abysmal prognosis. Unfortunately, our understanding of the biology underlying human BrMs remains rudimentary. Here, we present an integrative analysis of >100,000 malignant and non-malignant cells from 15 human parenchymal BrMs, generated by single-cell transcriptomics, mass cytometry, and complemented with mouse model- and in silico approaches. We interrogated the composition of BrM niches, molecularly defined the blood-tumor interface, and revealed stromal immunosuppressive states enriched with infiltrated T cells and macrophages. Specific single-cell interrogation of metastatic tumor cells provides a framework of 8 functional cell programs that coexist or anticorrelate. Collectively, these programs delineate two functional BrM archetypes, one proliferative and the other inflammatory, that are evidently shaped through tumor-immune interactions. Our resource provides a foundation to understand the molecular basis of BrM in patients with tumor cell-intrinsic and host environmental traits.

Indexed as

AdultAgedAnimalsBiomarkers, TumorBrain NeoplasmsCell CycleCell Line, TumorCell ProliferationFemaleGenetic VariationHumansImmune EvasionLymphocyte ActivationLymphocytes, Tumor-InfiltratingMiceMice, Inbred BALB CBiomarkers, Tumorblood tumor barrierCyTOFhuman metastasismetastasis-associated macrophagesmetastasis-infiltrated T cellsmetastatic nichemetastatic programmetastatic tumor cellsmetastatic tumorssingle cell

Identifiers

PMID35063085
PMCPMC8857062
OpenAlexW4206361954

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.