ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2022
Reactions of 3',5'-di-O-acetyl-2'-deoxyguansoine and 3',5'-di-O-acetyl-2'-deoxyadenosine to UV light in the presence of uric acid.
Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- Effects of additives on reaction of nucleosides with UV light in presence of uric acid and salicylic acid.Journal of clinical biochemistry and nutrition · 2022Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionRecently, it was revealed that uric acid is a photosensitizer of reactions of nucleosides on irradiation with UV light at wavelengths longer than 300 nm, and two products generated from 2'-deoxycytidine were identified. In the present study, UV reactions of acetylated derivatives of 2'-deoxyguansoine and 2'-deoxyadenosine were conducted and their products were identified.
findingsEach reaction of 3',5'-di-O-acetyl-2'-deoxyguansoine or 3',5'-di-O-acetyl-2'-deoxyadenosine with UV light at wavelengths longer than 300 nm in the presence of uric acid generated several products. The products were separated by HPLC and identified by comparing UV and MS spectra of the products with previously reported values. The major products were spiroiminodihydantoin, imidazolone, and dehydro-iminoallantoin nucleosides for 3',5'-di-O-acetyl-2'-deoxyguansoine, and an adenine base and a formamidopyrimidine nucleoside for 3',5'-di-O-acetyl-2'-deoxyadenosine.
conclusionsIf these damages caused by uric acid with sunlight occur in DNA of skin cells, mutations may arise. We should pay attention to the genotoxicity of uric acid in terms of DNA damage to dGuo and dAdo sites mediated by sunlight.
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