Evidence map›Paper›PMID 35063035›Full record

ArticleDiabetology & metabolic syndrome2022

Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis.

Ting Wang, Chaopeng Li, Min Shi, Shi Zhou, Jiajing Chen, Fang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  3. CircMETTL3 Inhibits HJournal of ophthalmology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ting WangDepartment of Ophthalmology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
Chaopeng LiDepartment of Ophthalmology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
Min ShiDepartment of Endocrinology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
Shi ZhouDepartment of Ophthalmology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
Jiajing ChenDepartment of Ophthalmology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
Fang WangDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, 301 Yan'an Zhong Lu, Jing'an District, Shanghai, 200071, China. wang_lucky0626@163.com.
Nanjing Medical University · CNSecond People’s Hospital of Huai’an · CNShanghai Tenth People's Hospital · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic retinopathy (DR) is a serious complication of diabetes. Numerous reports have validated that circular RNAs (circRNAs) participate in DR progression. This study aimed to elucidate the role and potential mechanism of circRNA zinc finger protein 532 (circZNF532) in DR.

methodsThe levels of circZNF532, miR-1243, and coactivator associated arginine methyltransferase 1 (CARM1) in DR patients and human retinal microvascular endothelial cells (hRMECs) were determined by quantitative real-time PCR and western blot. Colony formation assay, transwell assay, tube formation assay and enzyme-linked immunosorbent assay were used to assess the biological function of hRMECs. The binding relationship between miR-1243 and circZNF532/CARM1 was verified by dual-luciferase reporter and RNA immunoprecipitation assays.

resultscircZNF532 and CARM1 levels were increased, while miR-1243 level was reduced in DR patients and high glucose (HG)-stimulated hRMECs. In terms of mechanism, miR-1243 competitively bound to circZNF532 and CARM1. Down-regulation of circZNF532 restrained HG-induced hRMECs proliferation, migration, invasion, angiogenesis and inflammation via regulating miR-1243. In addition, miR-1243 inhibited HG-triggered hRMECs progression via targeting CARM1.

conclusioncircZNF532 facilitated HG-induced angiogenesis and inflammation in hRMECs via modulating the miR-1243/CARM1 pathway, suggesting that circZNF532 might be a potential biomarker for DR treatment.

Indexed as

CARM1circZNF532Diabetic retinopathyHigh glucosemiR-1243

Identifiers

PMID35063035
PMCPMC8780307
OpenAlexW4205417072

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.