ArticleInfectious agents and cancer2022
Bladder cancer and human papillomavirus association: a systematic review and meta-analysis.
Article in Infectious agents and cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intratumoral Human Papillomavirus in Advanced Prostate Cancer: Systematic Review, Meta-Analysis, and Real-World Evidence from the Largest Cohort to Date.International journal of molecular sciences · 2026Pooled it
- HPV-Associated Field Cancerization: Molecular Alterations in Histologically Normal Tissues and Implications for Early Detection and Cancer Prevention.Current issues in molecular biology · 2026Review
- Human papillomavirus type 16 and 18 in urothelial bladder neoplasms: detection, quantification, and comparison with non-neoplastic samples.Infectious agents and cancer · 2025Article
- Detection of High-Risk Human Papillomavirus in Bladder Cancer: An Exploratory Study from a UK-Based Population.Biomedicines · 2025Article
- Detection of Human Papillomavirus in Urogenital Swabs from Male Patients in Northern Serbia.Pathogens (Basel, Switzerland) · 2025Article
- The role and mechanism of human papillomavirus in urinary system tumors.The Journal of international medical research · 2025Review
- HPV-Associated Gene Signatures in Bladder Cancer: A Comprehensive Prognostic Model and its Implications in Immunotherapy.International journal of medical sciences · 2025Article
- Utility of The Paris System for Reporting Urinary Cytology in patients with HPV-positive urinary tract carcinoma.Cancer cytopathology · 2025Article
- Article
- Unveiling the Role of Human Papillomavirus in Urogenital Carcinogenesis a Comprehensive Review.Viruses · 2024Review
- A case of condyloma acuminatum of the bladder concurrently diagnosed with urothelial carcinoma.IJU case reports · 2024Article
- Unveiling the Association between HPV and Pan-Cancers: A Bidirectional Two-Sample Mendelian Randomization Study.Cancers · 2023Article
- Article
- New Hydronephrosis in the Native Kidney Is Associated with the Development of De Novo Urinary Bladder Urothelial Carcinoma in Patients with Post-Kidney Transplantation.Healthcare (Basel, Switzerland) · 2023Article
- The complexity of human papilloma virus in cancers: a narrative review.Infectious agents and cancer · 2023Review
- BK and JC polyomaviruses and risk of urothelial bladder carcinoma: a preliminary study in the northern shores of Persian Gulf, Iran.Infectious agents and cancer · 2022Article
- Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe possible association of human papillomavirus (HPV) and bladder cancer has been controversial. Older findings suggest a significant association between the virus and bladder cancer. The aim of this study was to evaluate the data from the last ten years to estimate the prevalence of the virus in bladder cancer patients and to assess the association between the virus and cancer.
methodA search of major databases was conducted to retrieve published English language studies between January 2011 and March 2021. In the present study overall prevalence of the virus in bladder cancer patients was estimated along with the prevalence of subgroups. Also, the possible associations between the prevalence of the virus and bladder cancer and the possible impact of variables in the geographical area and the type of sample were measured by comprehensive meta-analysis software (V2.2, BIOSTAT).
resultsUnlike previous studies, despite the relatively high prevalence of the virus [pooled prevalence: 14.3% (95% CI 8.9-22.2%)] no significant association was found between HPV and bladder cancer (OR 2.077, 95% CI 0.940-4.587). No significant association was found between geographical area (except Asia) and type of sample with bladder cancer.
conclusionsGiven the significant prevalence, despite the insignificance of the association between virus and cancer, it seems that more studies with case-control design are needed to elucidate this association.
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