Evidence map›Paper›PMID 35062972›Full record

ArticleJournal of nanobiotechnology2022

Bacteria-engineered porous sponge for hemostasis and vascularization.

Jie Bian, Luhan Bao, Xiaokang Gao, Xiao Wen, Qiang Zhang, Jinhua Huang, Zhenghui Xiong, Feng F Hong, Zili Ge, Wenguo Cui

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jie Bian *Department of Stomatology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, People's Republic of China.
Luhan Bao *Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People's Republic of China.
Xiaokang GaoDepartment of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, 368 Hanjiang Middle Road, Yangzhou, 225000, Jiangsu, People's Republic of China.
Xiao WenDepartment of Stomatology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, People's Republic of China.
Qiang ZhangDepartment of Stomatology, The Affiliated Hospital of Yangzhou University, Yangzhou University, 368 Hanjiang Middle Road, Yangzhou, 225000, Jiangsu, People's Republic of China.
Jinhua HuangDepartment of Stomatology, The Affiliated Hospital of Yangzhou University, Yangzhou University, 368 Hanjiang Middle Road, Yangzhou, 225000, Jiangsu, People's Republic of China.
Zhenghui XiongDepartment of Stomatology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, People's Republic of China.
Feng F HongScientific Research Base of Bacterial Nanofiber Manufacturing and Composite Technology, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, North Ren Min Road 2999, Shanghai, 201620, People's Republic of China.
Zili GeDepartment of Stomatology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, People's Republic of China. gezl@163.com.
Wenguo CuiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People's Republic of China. wgcui80@hotmail.com.ORCID http://orcid.org/0000-0002-6938-9582
Soochow University · CNYangzhou University · CNShanghai Jiao Tong University · CNDonghua University · CN

Funding

National Key Research and Development Program of China 2020YFA0908200National Natural Science Foundation of China 81930051Science and Technology Commission of Shanghai Municipality 19440760400Shanghai Jiao Tong University "Medical and Research" Program ZH2018ZDA04Shanghai Municipal Education Commission 20171906Shanghai Municipal Health Commission 20214Y0222Yangzhou Science and Technology Bureau YZ2021076
6 · The paper itself

Abstract

backgroundHemostasis and repair are two essential processes in wound healing, yet early hemostasis and following vascularization are challenging to address in an integrated manner.

resultsIn this study, we constructed a hemostatic sponge OBNC-DFO by fermentation of Komagataeibacter xylinus combined with TEMPO oxidation to obtain oxidized bacterial nanocellulose (OBNC). Then angiogenetic drug desferrioxamine (DFO) was grafted through an amide bond, and it promoted clot formation and activated coagulation reaction by rapid blood absorption due to the high total pore area (approximately 42.429 m

conclusionThis hemostatic and vascularization-promoting oxidized bacterial nanocellulose hemostatic sponge, which rapidly activates coagulation pathways and enables skin regeneration, is a highly promising hemostatic and pro-regenerative repair biomaterial.

Indexed as

BandagesBiocompatible MaterialsHemostaticsAnimalsBacteriaCells, CulturedCelluloseDeferoxamineHemorrhageHemostasisHumansHuman Umbilical Vein Endothelial CellsMaleNanostructuresNeovascularization, PathologicPorosityBiocompatible MaterialsCelluloseDeferoxamineHemostaticsDeferoxamineHemostasisOxidized bacterial nanocelluloseSpongeVascularization

Identifiers

PMID35062972
PMCPMC8780714
OpenAlexW4220796479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.