Evidence map›Paper›PMID 35062940›Full record

SynthesisBMC oral health2022

Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis.

Claudia Arena, Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Lucio Lo Russo, Lorenzo Lo Muzio, Giuseppe Troiano

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06856369 (Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06856369 phase4active not recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis

TypeinterventionalSponsorBahria UniversityRan2025 to 2027Enrolled120ConditionsAlveolar Bone Loss Associated Chronic PeriodontitisArmsPlatelet rich fibrin, Metformin hydrochloride powder, alendronate sodium powder
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Zoledronic acid affects the process ofFrontiers in cellular and infection microbiology · 2023
    Article
  4. Roles of osteoclasts in alveolar bone remodeling.Genesis (New York, N.Y. : 2000) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Claudia ArenaDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.
Vito Carlo Alberto CaponioDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.
Khrystyna ZhurakivskaDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.
Lucio Lo RussoDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.
Giuseppe TroianoDepartment of Clinical and Experimental Medicine, University of Foggia, 71122, Foggia, Italy. giuseppe.troiano@unifg.it.
University of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis systematic review and meta-analysis aimed to investigate the role of alendronate combined with step 2 of periodontal therapy in reducing probing pocket depth, improving clinical attachment level, and reducing bone defect depth in intra-bony and inter-radicular defects.

methodsRCTs with more than 6 months follow-up were included in this study. Risk of bias assessment was performed using the Cochrane collaboration tool. In addition, meta-analysis and trial sequential analysis were used to aggregate the available evidence.

resultsSeven studies met the inclusion criteria and were included in the systematic review. Topical application of alendronate during second step of periodontal therapy significantly improved PD and CAL.

conclusionLocal application of alendronate may confer a beneficial effect when applied during step II of periodontal therapy even if long term studies are needed to confirm these results. CLINICAL RELEVANCE: Considering the emerging role of host-inflammatory response in treatment of periodontitis and the antiresorptive and osteostimulative properties of bisphosphonates, several studies are focusing on the role of alendronate as an addition to non-surgical periodontal therapy.

Indexed as

Alveolar Bone LossPeriodontitisAlendronateDiphosphonatesHumansPeriodontal Attachment LossAlendronateDiphosphonatesAlendronateMeta-analysisNon-surgical treatmentPeriodontal defectsPeriodontitisSystematic review

Identifiers

PMID35062940
PMCPMC8780760
OpenAlexW4206983395

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.