Evidence map›Paper›PMID 35062912›Full record

SynthesisBMC cancer2022

Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies.

Golnoosh Goodarzi, Hadis Mozaffari, Tahereh Raeisi, Fatemeh Mehravar, Bahman Razi, Maryam Lafzi Ghazi, Nazila Garousi, Shahab Alizadeh, Parisa Janmohammadi

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Golnoosh GoodarziDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Hadis MozaffariFaculty of Land and Food Systems, University of British Columbia, Vancouver, Canada.
Tahereh RaeisiDepartment of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Fatemeh MehravarDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Bahman RaziDepartment of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Maryam Lafzi GhaziDepartment of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Nazila GarousiDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Shahab AlizadehDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Tehran Province, Iran.
Parisa JanmohammadiDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Tehran Province, Iran. p-janmohammadi@alumnus.tums.ac.ir.
Tehran University of Medical Sciences · IRHormozgan University of Medical Sciences · IRIsfahan University of Medical Sciences · IRIslamic Azad University Central Tehran Branch · IRIslamic Azad University, Science and Research Branch · IRTarbiat Modares University · IRUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association of obesity with colorectal cancer (CRC) may vary depending on metabolic status.

objectiveThis meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk.

methodsThe Scopus, PubMed, and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight (MUHNW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUHO) phenotypes.

resultsA total of 7 cohort studies with a total of 759,066 participants were included in this meta-analysis. Compared with healthy normal-weight people, MUHNW, MHO, and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 1.19 (95% CI = 1.09-1.31) in MUHNW, 1.14 (95% CI = 1.06-1.22) in MHO, and 1.24 (95% CI = 1.19-1.29) in MUHO subjects. When analyses were stratified based on gender, associations remained significant for males. However, the elevated risk of CRC associated with MHO and MUHO was not significant in female participants.

conclusionsThe individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status.

Indexed as

Body WeightAdultAgedBody Mass IndexCohort StudiesColorectal NeoplasmsFemaleHumansIdeal Body WeightMaleMetabolic DiseasesMiddle AgedObesityObesity, Metabolically BenignOdds RatioPhenotypeColorectal cancerObesityPhenotypes

Identifiers

PMID35062912
PMCPMC8781040
OpenAlexW4205463212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.