Evidence map›Paper›PMID 35062871›Full record

SynthesisBMC anesthesiology2022

Unfractionated heparin improves the clinical efficacy in adult sepsis patients: a systematic review and meta-analysis.

Sifeng Fu, Sihan Yu, Liang Wang, Xiaochun Ma, Xu Li

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Guideline
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  16. Why anticoagulant studies on sepsis fail frequently --- start with SCARLET.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2023
    Article
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sifeng FuDepartment of Critical Care Medicine, the First Affiliated Hospital of China Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning Province, China.
Sihan YuDepartment of Critical Care Medicine, the First Affiliated Hospital of China Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning Province, China.
Liang WangDepartment of Critical Care Medicine, the First Affiliated Hospital of China Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning Province, China.
Xiaochun MaDepartment of Critical Care Medicine, the First Affiliated Hospital of China Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning Province, China.
Xu LiDepartment of Critical Care Medicine, the First Affiliated Hospital of China Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning Province, China. vincentzh002@outlook.com.
China Medical University · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe anticoagulant treatment and clinical efficacy of heparin in sepsis remains controversial. We conducted a meta-analysis to estimate the clinical efficacy of unfractionated heparin (UFH) in adult septic patients.

methodA systematic review of Medline, Cochrane Library, PubMed, Embase, WEIPU database, CNKI database, WANFANG database was performed from inception to January 2021. We included Randomized controlled trials (RCTs) and the main outcome was 28 d mortality. Data analysis was performed with Review Manager (RevMan) version 5.3 software. The meta-analysis included 2617 patients from 15 RCTs.

resultsComparing to control group, UFH could reduce 28 d mortality (RR: 0.82; 95% CI: 0.72 to 0.94) especially for patient with Acute Physiology and Chronic Health Evaluation II (APACHE II) > 15, (RR: 0.83; 95% CI: 0.72 to 0.96). In UFH group, the platelet (PLT) (MD: 9.18; 95% CI: 0.68 to 17.68) was higher, the activated partial thromboplastin time (APTT) was shorter (MD: -8.01; 95% CI: - 13.84 to - 2.18) and the prothrombin time (PT) results (P > 0.05) failed to reach statistical significance. UFH decreased multiple organ dysfunction syndrome (MODS) incidence (RR: 0.61; 95% CI: 0.45 to 0.84), length of stay (LOS) in ICU (MD: -4.94; 95% CI: - 6.89 to - 2.99) and ventilation time (MD: -3.01; 95% CI: - 4.0 to - 2.02). And UFH had no adverse impact on bleeding (RR: 1.10; 95% CI: 0.54 to 2.23).

conclusionThis meta-analysis suggests that UFH may reduce 28 d mortality and improve the clinical efficacy in sepsis patients without bleeding adverse effect.

Indexed as

AdultAnticoagulantsHeparinHumansSepsisTreatment OutcomeAnticoagulantsHeparinAnticoagulant treatmentMeta-analysisSepsisSeptic shockUnfractionated heparin

Identifiers

PMID35062871
PMCPMC8777179
OpenAlexW4206929673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.