Evidence map›Paper›PMID 35062860›Full record

ArticleThe journal of headache and pain2022

Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model.

Tzu-Ting Liu, Andreia Morais, Tsubasa Takizawa, Inge Mulder, Bruce J Simon, Shih-Pin Chen, Shuu-Jiun Wang, Cenk Ayata, Jiin-Cherng Yen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
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  7. Article
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  11. Vagus Nerve Stimulation in Ischemic Stroke.Current neurology and neuroscience reports · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tzu-Ting Liu *Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, 5th floor, Shouren Building, No. 155, Sec. 2, Linong St., Beitou District, 112, Taipei, Taiwan.
Andreia Morais *Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Tsubasa TakizawaNeurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Inge MulderNeurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Bruce J SimonelectroCore, Inc, Basking Ridge, NJ, USA.
Shih-Pin ChenDepartment of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.
Shuu-Jiun WangDepartment of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.
Cenk Ayata *Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Jiin-Cherng Yen *Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, 5th floor, Shouren Building, No. 155, Sec. 2, Linong St., Beitou District, 112, Taipei, Taiwan. jcyen@ym.edu.tw.

Funding

Massachusetts General Hospital Claflin Distinguished AwardMinistry of Science and Technology, Taiwan MOST 107-2314-B-010-021Ministry of Science and Technology, Taiwan MOST 108-2314-B-010-022-MY3Ministry of Science and Technology, Taiwan MOST 108-2314-B-010-023Ministry of Science and Technology, Taiwan MOST 108-2321-B-010-001Ministry of Science and Technology, Taiwan MOST 108-2321-B-010-014-MY2Ministry of Science and Technology, Taiwan MOST-109-2314-B-010-040Ministry of Science and Technology, Taiwan MOST 110-2321-B-010-005Ministry of Science and Technology, Taiwan MOST 110-2326-B-A49A-501-MY3National Yang-Ming University Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of EducationNIH HHS R01-2016D007667Taipei Veterans General Hospital V110C-102, V109D52-001-MY3-2, VGHUST110-G-3-1Taipei Veterans General Hospital VGH-106-D9-001-MY2-2Yin Yen-Liang Foundation Development and Construction Plan of the College of Medicine, National Yang Ming Chiao Tung University Yin Yen-Liang Foundation Development and Construction Plan of the College of Medicine, National Yang Ming Chiao Tung University
6 · The paper itself

Abstract

backgroundNoninvasive vagus nerve stimulation (nVNS) has recently emerged as a promising therapy for migraine. We previously demonstrated that vagus nerve stimulation inhibits cortical spreading depression (CSD), the electrophysiological event underlying migraine aura and triggering headache; however, the optimal nVNS paradigm has not been defined.

methodsVarious intensities and doses of nVNS were tested to improve efficacy on KCl-evoked CSD frequency and electrical threshold of CSD in a validated rat model. Chronic efficacy was evaluated by daily nVNS delivery for four weeks. We also examined the effects of nVNS on neuroinflammation and trigeminovascular activation by western blot and immunohistochemistry.

resultsnVNS suppressed susceptibility to CSD in an intensity-dependent manner. Two 2-minute nVNS 5 min apart afforded the highest efficacy on electrical CSD threshold and frequency of KCl-evoked CSD. Daily nVNS for four weeks did not further enhance efficacy over a single nVNS 20 min prior to CSD. The optimal nVNS also attenuated CSD-induced upregulation of cortical cyclooxygenase-2, calcitonin gene-related peptide in trigeminal ganglia, and c-Fos expression in trigeminal nucleus caudalis.

conclusionsOur study provides insight on optimal nVNS parameters to suppress CSD and suggests its benefit on CSD-induced neuroinflammation and trigeminovascular activation in migraine treatment.

Indexed as

Cortical Spreading DepressionMigraine DisordersVagus Nerve StimulationAnimalsHeadacheNeuroinflammatory DiseasesRatsCortical spreading depressionNeuroinflammationTrigeminal activationVagus nerve stimulation

Identifiers

PMID35062860
PMCPMC8903561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.