Evidence map›Paper›PMID 35062785›Full record

ArticleVaccines2022

Immunoprofiling Identifies Functional B and T Cell Subsets Induced by an Attenuated Whole Parasite Malaria Vaccine as Correlates of Sterile Immunity.

Marie Mura, Pinyi Lu, Tanmaya Atre, Jessica S Bolton, Elizabeth H Duncan, Sidhartha Chaudhury, Elke S Bergmann-Leitner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Human transcriptional signature of protection afterHuman vaccines & immunotherapeutics · 2023
    Article
  6. [Malaria today].Medecine tropicale et sante internationale · 2023
    Article
  7. Profiling of serum factors associated withFrontiers in immunology · 2023
    Article
  8. Article
  9. [Exploration of vaccine immunogenicity].Revue francophone des laboratoires : RFL · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Marie MuraBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-0051-3773
Pinyi LuBiotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD 21702, USA.
Tanmaya AtreBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-9863-691X
Jessica S BoltonBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Elizabeth H DuncanBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-1943-1113
Sidhartha ChaudhuryCenter for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Elke S Bergmann-LeitnerBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-8571-8956
Walter Reed Army Institute of Research · USHenry M. Jackson Foundation · USBC Children's Hospital · CA

Funding

Military Infectious Disease Research Program (F0570_19_WR)
6 · The paper itself

Abstract

Immune correlates of protection remain elusive for most vaccines. An identified immune correlate would accelerate the down-selection of vaccine formulations by reducing the need for human pathogen challenge studies that are currently required to determine vaccine efficacy. Immunization via mosquito-delivered, radiation-attenuated

Indexed as

correlate of protectionimmune signaturemachine learningmalariawhole sporozoites vaccine

Identifiers

PMID35062785
PMCPMC8780163
OpenAlexW4205329448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.