Evidence map›Paper›PMID 35062673›Full record

ArticleVaccines2021

Pfizer-BioNTech COVID-19 Vaccine in Gynecologic Oncology Patients: A Prospective Cohort Study.

Innocenza Palaia, Giuseppe Caruso, Violante Di Donato, Annarita Vestri, Anna Napoli, Giorgia Perniola, Matteo Casinelli, Danilo Alunni Fegatelli, Roberta Campagna, Federica Tomao and 3 more

Abstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Innocenza PalaiaDepartment of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Giuseppe CarusoDepartment of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-5501-1936
Violante Di DonatoDepartment of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-9254-5790
Annarita VestriDepartment of Public Health and Infectious Diseases, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-6139-7174
Anna NapoliDepartment of Molecular Medicine, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Giorgia PerniolaDepartment of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Matteo CasinelliDepartment of Molecular Medicine, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Danilo Alunni FegatelliDepartment of Public Health and Infectious Diseases, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Roberta CampagnaDepartment of Molecular Medicine, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Federica TomaoDepartment of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Debora D'AnielloDepartment of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Guido AntonelliDepartment of Molecular Medicine, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.
Ludovico MuziiDepartment of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-7195-9583

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the safety and immunogenicity of the Pfizer-BioNTech COVID-19 vaccine in gynecologic oncology patients under chemotherapy.

methodsA prospective cohort study including gynecologic oncology women who were under chemotherapy or had completed it within 6 months at the time of the study. All patients received a two-dose schedule of the Pfizer-BioNTech COVID-19 vaccine. Results were compared with a control group of healthy women vaccinated in the same period.

resultsOverall, 44 oncologic patients with a mean age of 61.3 ± 10.7 years were enrolled: 28 (63.6%) had ovarian cancer, 9 (20.4%) endometrial, and 7 (16%) cervical. The IgG antibody titer after 1 month from vaccination was low in 9 (20.5%) patients, moderate in 21 (47.7%), and high in 14 (31.8%). The 3-month titer was null in 2 (4.5%) patients, low in 26 (59.1%), moderate in 13 (29.5%), and high in 3 (6.8%). Patients ≥ 50 years reported lower 1-month (

conclusionsThe COVID-19 vaccine was safe and immunogenic in gynecologic oncology patients under chemotherapy. Serological monitoring and further vaccine shots should be considered to boost protection.

Indexed as

cancerchemotherapyCOVID-19gynecologic oncologySARS-CoV-2vaccine

Identifiers

PMID35062673
PMCPMC8780883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.