ArticleViruses2022
Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes.
Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Differentiating Cell Entry Potentials of SARS-CoV-2 Omicron Subvariants on Human Lung Epithelium Cells.Viruses · 2024Article
- Genetic diversity and genomic epidemiology of SARS-CoV-2 during the first 3 years of the pandemic in Morocco: comprehensive sequence analysis, including the unique lineage B.1.528 in Morocco.Access microbiology · 2024Article
- Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission.Nature microbiology · 2022Article
- Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron.iScience · 2022Article
- Article
- Insights into the limited global spread of the immune evasive SARS-CoV-2 variant Mu.medRxiv : the preprint server for health sciences · 2022Article
- A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues.bioRxiv : the preprint server for biology · 2022Article
- Coinfection of fungi with SARS-CoV-2 is a detrimental health risk for COVID-19 patients.Beni-Suef University journal of basic and applied sciences · 2022Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid emergence of SARS-CoV-2 variants is fueling the recent waves of the COVID-19 pandemic. Here, we assessed ACE2 binding and antigenicity of Mu (B.1.621) and A.2.5 Spikes. Both these variants carry some mutations shared by other emerging variants. Some of the pivotal mutations such as N501Y and E484K in the receptor-binding domain (RBD) detected in B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma) are now present within the Mu variant. Similarly, the L452R mutation of B.1.617.2 (Delta) variant is present in A.2.5. In this study, we observed that these Spike variants bound better to the ACE2 receptor in a temperature-dependent manner. Pseudoviral particles bearing the Spike of Mu were similarly neutralized by plasma from vaccinated individuals than those carrying the Beta (B.1.351) and Delta (B.1.617.2) Spikes. Altogether, our results indicate the importance of measuring critical parameters such as ACE2 interaction, plasma recognition and neutralization ability of each emerging variant.
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